The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue
DC Field | Value | Language |
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dc.contributor.author | 정나나 | - |
dc.contributor.author | 박종훈 | - |
dc.contributor.author | 임기원 | - |
dc.date.accessioned | 2021-09-03T14:10:40Z | - |
dc.date.available | 2021-09-03T14:10:40Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86158 | - |
dc.description.abstract | [Purpose] The purpose of this study was to determine whether exercise or/and cold exposure regulate mitochondria biogenesis-related gene expression in soleus and inguinal adipose tissue of mice. [Methods] Forty ICR 5-week old male mice were divided into four groups: thermoneutrality-untrained (23 ± 1 °C in room temperature, n=10), cold-water immersion (24 ± 1 °C, n=10), exercise in neutral temperature (34 ± 1 °C, n=10), and exercise in cold temperature (24 ± 1 °C, n=10). The mice performed swimming exercise (30 min to 60 min, 5 times) for 8 weeks. After 8 weeks, we confirmed mitochondrial biogenesis-related gene expression changes for peroxisome proliferator- activated receptor gamma coactivator-1 alpha (PGC-1α), nuclear respiratory factors 1 (NRF1), and mitochondrial transcription factor A (Tfam) in soleus muscle and inguinal adipose tissue, and the related protein expression in soleus muscle. [Results] In soleus muscle, PGC-1α expression significantly increased in response to cold exposure (p = 0.006) and exercise (p = 0.05). There was also significant interaction between exercise and cold exposure (p = 0.005). Only exercise had a significant effect on NRF1 relative expression (p=0.001). Neither cold exposure nor the interaction showed significant effects (p = 0.1222 and p = 0.875, respectively). Relative Tfam expression did not show any significant effect from exercise. In inguinal adipose tissue, relative PGC-1α expression did not significantly change in any group. NRF1 expression showed a significant change from exercise (p = 0.01) and cold exposure (p = 0.011). There was also a significant interaction between exercise and cold exposure (p = 0.000). Tfam mRNA expression showed a significant effect from exercise (p=0.000) and an interaction between exercise and cold exposure (p=0.001). Only temperature significantly affected PGC-1α protein levels (p=0.045). Neither exercise nor the interaction were significant (p = 0.397 and p = 0.292, respectively). NRF1 protein levels did not show a significant effect in any experimental treatments. Tfam protein levels showed a significant effect in the exercise group (p=0.012), but effects of neither cold exposure nor the interaction were significant (p = 0.085 and p=0.374, respectively). [Conclusion] Exercise and cold exposure promoted increased expression of mitochondrial biogenesis- related genes in soleus muscle. Only cold exposure had a significant effect on PGC-1α protein expression and only exercise had a significant effect on Tfam protein expression. In inguinal adipose tissue, there was interaction between exercise and cold exposure in expression of mitochondrial biogenesis- related genes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국운동영양학회 | - |
dc.title | The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue | - |
dc.title.alternative | The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 박종훈 | - |
dc.identifier.doi | 10.20463/jenb.2017.0020 | - |
dc.identifier.bibliographicCitation | Physical Activity and Nutrition, v.21, no.2, pp.39 - 47 | - |
dc.relation.isPartOf | Physical Activity and Nutrition | - |
dc.citation.title | Physical Activity and Nutrition | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 47 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002241381 | - |
dc.description.journalClass | 3 | - |
dc.subject.keywordAuthor | Exercise | - |
dc.subject.keywordAuthor | Cold exposure | - |
dc.subject.keywordAuthor | PGC-1α | - |
dc.subject.keywordAuthor | NRF-1 | - |
dc.subject.keywordAuthor | Tfam | - |
dc.subject.keywordAuthor | Mitochondrial biogenesis. | - |
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