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MicroRNA signatures associated with thioacetamide-induced liver fibrosis in mice

Authors
Hong, Jae-SangLee, Do-HoonYook, Ye WonNa, DokyunJang, Yu JinKim, Jong-HoonLee, Young Sik
Issue Date
2017
Publisher
TAYLOR & FRANCIS LTD
Keywords
microRNA; liver fibrosis; thioacetamide; deep sequencing
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.81, no.7, pp.1348 - 1355
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
81
Number
7
Start Page
1348
End Page
1355
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/86240
DOI
10.1080/09168451.2017.1308242
ISSN
0916-8451
Abstract
Multiple etiologies of liver injury are associated with fibrosis in which the key event is the activation of hepatic stellate cells (HSCs). Although microRNAs (miRNAs) are reportedly involved in fibrogenesis, the complete array of miRNA signatures associated with the disease has yet to be elucidated. Here, deep sequencing analysis revealed that compared to controls, 80 miRNAs were upregulated and 21 miRNAs were downregulated significantly in the thioacetamide (TAA)-induced mouse fibrotic liver. Interestingly, 58 of the upregulated miRNAs were localized to an oncogenic miRNA megacluster upregulated in liver cancer. Differential expression of some of the TAA-responsive miRNAs was confirmed, and their human orthologs were similarly deregulated in TGF-1-activated HSCs. Moreover, a functional analysis of the experimentally validated high-confidence miRNA targets revealed significant enrichment for the GO terms and KEGG pathways involved in HSC activation and liver fibrogenesis. This is the first comprehensive report of miRNAs profiles during TAA-induced mouse liver fibrosis.
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