Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism
DC Field | Value | Language |
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dc.contributor.author | Choi-Kwon, Smi | - |
dc.contributor.author | Ko, Mihye | - |
dc.contributor.author | Jun, Sang-Eun | - |
dc.contributor.author | Kim, Juhan | - |
dc.contributor.author | Cho, Kyung-Hee | - |
dc.contributor.author | Nah, Hyun-Wook | - |
dc.contributor.author | Song, Hasup | - |
dc.contributor.author | Kim, Jong S. | - |
dc.date.accessioned | 2021-09-03T14:48:29Z | - |
dc.date.available | 2021-09-03T14:48:29Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1015-9770 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86245 | - |
dc.description.abstract | Background: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. Methods: A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70 degrees C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A). Results: Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity MAOA was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low MAO-A activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients. Conclusions: Our findings suggest that PSF may be associated with a genetic polymorphism involving MAO-A, at least in female stroke patients. (C) 2016 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | QUALITY-OF-LIFE | - |
dc.subject | STROKE PATIENTS | - |
dc.subject | MULTIPLE-SCLEROSIS | - |
dc.subject | ISCHEMIC-STROKE | - |
dc.subject | POPULATION | - |
dc.subject | DEPRESSION | - |
dc.title | Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Kyung-Hee | - |
dc.identifier.doi | 10.1159/000450894 | - |
dc.identifier.scopusid | 2-s2.0-84996671101 | - |
dc.identifier.wosid | 000394585600009 | - |
dc.identifier.bibliographicCitation | CEREBROVASCULAR DISEASES, v.43, no.1-2, pp.54 - 58 | - |
dc.relation.isPartOf | CEREBROVASCULAR DISEASES | - |
dc.citation.title | CEREBROVASCULAR DISEASES | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 58 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | STROKE PATIENTS | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Gene | - |
dc.subject.keywordAuthor | Fatigue | - |
dc.subject.keywordAuthor | Depression | - |
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