Melatonin mitigates neomycin-induced hair cell injury in zebrafish
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Kyoung Ho | - |
dc.contributor.author | Rah, Yoon Chan | - |
dc.contributor.author | Hwang, Kyu Ho | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Kwon, Soon Young | - |
dc.contributor.author | Cha, Jae Hyung | - |
dc.contributor.author | Choi, June | - |
dc.date.accessioned | 2021-09-03T14:50:33Z | - |
dc.date.available | 2021-09-03T14:50:33Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0148-0545 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86256 | - |
dc.description.abstract | Context: Ototoxicity due to medications, such as aminoglycosides, is irreversible, and free radicals in the inner ear are assumed to play a major role. Because melatonin has an antioxidant property, we hypothesize that it might mitigate hair cell injury by aminoglycosides. Objective: The objective of this study was to evaluate whether melatonin has an alleviative effect on neomycin-induced hair cell injury in zebrafish (Danio rerio). Methods: Various concentrations of melatonin were administered to 5-day post-fertilization zebrafish treated with 125 mu M neomycin for 1 h. Surviving hair cells within four neuromasts were compared with that of a control group. Apoptosis was assessed via terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. The changes of ultrastructure were confirmed using a scanning electron microscope. Results: Melatonin alleviated neomycin-induced hair cell injury in neuromasts (neomycin+melatonin 100 mu M: 13.88 +/- 0.91 cells, neomycin only: 7.85 +/- 0.90 cells; n=10, p<0.05) and reduced neomycin-induced apoptosis in the TUNEL assay. In ultrastructural analysis, hair cells within the neuromasts in zebrafish were preserved exposed to 125 mu M neomycin and 100 mu M melatonin for 1 h in SEM findings. Conclusion: Melatonin is effective in alleviating aminoglycoside-induced hair cell injury in zebrafish. The results of this study demonstrated that melatonin has the potential to reduce apoptosis induced by aminoglycosides in zebrafish. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | PROTECTIVE ROLE | - |
dc.subject | GENTAMICIN | - |
dc.subject | OTOTOXICITY | - |
dc.subject | DAMAGE | - |
dc.subject | HEARING | - |
dc.subject | REVEALS | - |
dc.title | Melatonin mitigates neomycin-induced hair cell injury in zebrafish | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rah, Yoon Chan | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hoon | - |
dc.contributor.affiliatedAuthor | Kwon, Soon Young | - |
dc.contributor.affiliatedAuthor | Choi, June | - |
dc.identifier.doi | 10.1080/01480545.2016.1244679 | - |
dc.identifier.scopusid | 2-s2.0-84995560932 | - |
dc.identifier.wosid | 000406544200003 | - |
dc.identifier.bibliographicCitation | DRUG AND CHEMICAL TOXICOLOGY, v.40, no.4, pp.390 - 396 | - |
dc.relation.isPartOf | DRUG AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | DRUG AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 390 | - |
dc.citation.endPage | 396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | PROTECTIVE ROLE | - |
dc.subject.keywordPlus | GENTAMICIN | - |
dc.subject.keywordPlus | OTOTOXICITY | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | HEARING | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordAuthor | Melatonin | - |
dc.subject.keywordAuthor | aminoglycoside | - |
dc.subject.keywordAuthor | zebrafish | - |
dc.subject.keywordAuthor | ototoxicity | - |
dc.subject.keywordAuthor | protection | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.