Parkinson's disease might increase the risk of cerebral ischemic lesions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, In-Uk | - |
dc.contributor.author | Lee, Ji-Eun | - |
dc.contributor.author | Kwon, Do-Young | - |
dc.contributor.author | Park, Jeong-Ho | - |
dc.contributor.author | Ma, Hyeo-Il | - |
dc.date.accessioned | 2021-09-03T14:52:42Z | - |
dc.date.available | 2021-09-03T14:52:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86269 | - |
dc.description.abstract | Background: Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. Cerebrovascular diseases such as cerebral ischemic lesion (CIL) also commonly occur in elderly adults. However, previous studies on the relationship between PD and cerebrovascular disease have not found consistent results. Therefore, we conducted this study to evaluate whether or not PD is related to an increased prevalence of ischemic cerebrovascular lesions. Methods: This study recruited 241 patients with PD and 112 healthy controls (HCs). All subjects underwent brain magnetic resonance imaging and general neuropsychological tests. The motor severity of PD was evaluated according to the Hoehn and Yahr stage (HY stage), and the severity of CIL in all subjects was classified according to Fazekas grade. The PD patients were classified into two subgroups according to HY stage (Group 1 - HY 1, 2; Group 2 - HY 3 to 5). Results: Among all PD patients, 76% had small vessel disease, while 44% of all HCs had small vessel disease (p<0.001). Regarding the difference between the two subgroups according to motor severity, group 2 showed significantly higher Fazekas scale score and more severe CIL, indicating a higher prevalence of small vessel disease compared to group 1. Conclusion: This study demonstrates that PD patients have a significantly higher prevalence of CIL compared to HCs. Therefore, although the present study is not a large-scale study, we cautiously suggest that PD can play an important role as a risk factor in the occurrence of ischemic cerebrovascular disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IVYSPRING INT PUBL | - |
dc.subject | STROKE | - |
dc.title | Parkinson's disease might increase the risk of cerebral ischemic lesions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Do-Young | - |
dc.identifier.doi | 10.7150/ijms.18025 | - |
dc.identifier.scopusid | 2-s2.0-85016159215 | - |
dc.identifier.wosid | 000401118900003 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, v.14, no.4, pp.319 - 322 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 319 | - |
dc.citation.endPage | 322 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | cerebral ischemic lesion | - |
dc.subject.keywordAuthor | Fazekas scale | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.