Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Oh, Seikwan | - |
dc.contributor.author | Yoo, Hwan-Soo | - |
dc.date.accessioned | 2021-09-03T14:55:21Z | - |
dc.date.available | 2021-09-03T14:55:21Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0257-2753 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86285 | - |
dc.description.abstract | Background: The increased risk of gallstone has been reported in patients with ATP-binding cassette (ABC) transporter polymorphism. The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine. We investigated whether ceramide plays a role in cholesterol efflux through the ABC transporters. Methods: Six-week-old C57BL/6J mice were assigned to 3 groups. The normal group (n = 5) was fed a normal chow diet, the cholesterol group (n = 10) was fed a lithogenic diet, and the myriocin group (n = 15) was fed the lithogenic diet and myriocin, a specific inhibitor of serine-palmitoyl transferase. After 6 weeks, the ABCG5 and ABCG8 transporters were analyzed. Results: The rate of cholesterol gallstone formation in cholesterol group was also higher than that in normal and myriocin groups (0, 70, and 40%, respectively). ABCG5 and ABCG8 mRNA levels were significantly increased in cholesterol group and less increased in myriocin group, relative to that in normal group (p < 0.05). Conclusions: The inhibition of ceramide biosynthesis by myriocin suppressed gallstone formation and ABCG5/8 mRNA expression. We expect that ceramide's role as a regulator of the ABCG5/8 transporter might be linked to cholesterol gallstone formation. (C) 2017 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | MICE | - |
dc.subject | DISEASE | - |
dc.subject | ABCG8 | - |
dc.title | Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jae Seon | - |
dc.identifier.doi | 10.1159/000465517 | - |
dc.identifier.scopusid | 2-s2.0-85015649390 | - |
dc.identifier.wosid | 000407921900003 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES, v.35, no.5, pp.439 - 443 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES | - |
dc.citation.title | DIGESTIVE DISEASES | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 439 | - |
dc.citation.endPage | 443 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ABCG8 | - |
dc.subject.keywordAuthor | ATP-binding cassette transporter G5 | - |
dc.subject.keywordAuthor | ATP-binding cassette transporter G8 | - |
dc.subject.keywordAuthor | Ceramide | - |
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