Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy
DC Field | Value | Language |
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dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Chung, Jong-Won | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Jang, Min Uk | - |
dc.contributor.author | Noh, Hyun-Du | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Ko, Youngchai | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Nah, Hyun-Wook | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Park, Sang-Soon | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi-Sun | - |
dc.contributor.author | Cho, Ki-Hyun | - |
dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Kim, Wook-Joo | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Yeo, Min-Ju | - |
dc.contributor.author | Sohn, Sung Il | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2021-09-03T14:55:31Z | - |
dc.date.available | 2021-09-03T14:55:31Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1015-9770 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86286 | - |
dc.description.abstract | Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 +/- 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months. (C) 2017 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject | IMAGING SELECTION | - |
dc.subject | SYMPTOM ONSET | - |
dc.subject | T-PA | - |
dc.subject | TRIAL | - |
dc.subject | THROMBECTOMY | - |
dc.subject | RECANALIZATION | - |
dc.subject | ALTEPLASE | - |
dc.subject | REVASCULARIZATION | - |
dc.title | Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1159/000471492 | - |
dc.identifier.scopusid | 2-s2.0-85018273690 | - |
dc.identifier.wosid | 000407161400008 | - |
dc.identifier.bibliographicCitation | CEREBROVASCULAR DISEASES, v.44, no.1-2, pp.51 - 58 | - |
dc.relation.isPartOf | CEREBROVASCULAR DISEASES | - |
dc.citation.title | CEREBROVASCULAR DISEASES | - |
dc.citation.volume | 44 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 51 | - |
dc.citation.endPage | 58 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | IMAGING SELECTION | - |
dc.subject.keywordPlus | SYMPTOM ONSET | - |
dc.subject.keywordPlus | T-PA | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | THROMBECTOMY | - |
dc.subject.keywordPlus | RECANALIZATION | - |
dc.subject.keywordPlus | ALTEPLASE | - |
dc.subject.keywordPlus | REVASCULARIZATION | - |
dc.subject.keywordAuthor | Preceding intravenous thrombolysis | - |
dc.subject.keywordAuthor | Endovascular therapy | - |
dc.subject.keywordAuthor | Functional outcome | - |
dc.subject.keywordAuthor | Acute ischemic stroke | - |
dc.subject.keywordAuthor | Comparative effectiveness research | - |
dc.subject.keywordAuthor | Acute stroke therapy | - |
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