Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schmitt, Andrea | - |
dc.contributor.author | Martins-de-Souza, Daniel | - |
dc.contributor.author | Akbarian, Schahram | - |
dc.contributor.author | Cassoli, Juliana S. | - |
dc.contributor.author | Ehrenreich, Hannelore | - |
dc.contributor.author | Fischer, Andre | - |
dc.contributor.author | Fonteh, Alfred | - |
dc.contributor.author | Gattaz, Wagner F. | - |
dc.contributor.author | Gawlik, Michael | - |
dc.contributor.author | Gerlach, Manfred | - |
dc.contributor.author | Grunblatt, Edna | - |
dc.contributor.author | Halene, Tobias | - |
dc.contributor.author | Hasan, Alkomiet | - |
dc.contributor.author | Hashimoto, Kenij | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Kirchner, Sophie-Kathrin | - |
dc.contributor.author | Kornhuber, Johannes | - |
dc.contributor.author | Kraus, Theo F. J. | - |
dc.contributor.author | Malchow, Berend | - |
dc.contributor.author | Nascimento, Juliana M. | - |
dc.contributor.author | Rossner, Moritz | - |
dc.contributor.author | Schwarz, Markus | - |
dc.contributor.author | Steiner, Johann | - |
dc.contributor.author | Talib, Leda | - |
dc.contributor.author | Thibaut, Florence | - |
dc.contributor.author | Riederer, Peter | - |
dc.contributor.author | Falkai, Peter | - |
dc.date.accessioned | 2021-09-03T15:30:13Z | - |
dc.date.available | 2021-09-03T15:30:13Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1562-2975 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86482 | - |
dc.description.abstract | Objectives: Despite progress in identifying molecular pathophysiological processes in schizophrenia, valid biomarkers are lacking for both the disease and treatment response. Methods: This comprehensive review summarises recent efforts to identify molecular mechanisms on the level of protein and gene expression and epigenetics, including DNA methylation, histone modifications and micro RNA expression. Furthermore, it summarises recent findings of alterations in lipid mediators and highlights inflammatory processes. The potential that this research will identify biomarkers of schizophrenia is discussed. Results: Recent studies have not identified clear biomarkers for schizophrenia. Although several molecular pathways have emerged as potential candidates for future research, a complete understanding of these metabolic pathways is required to reveal better treatment modalities for this disabling condition. Conclusions: Large longitudinal cohort studies are essential that pair a thorough phenotypic and clinical evaluation for example with gene expression and proteome analysis in blood at multiple time points. This approach might identify biomarkers that allow patients to be stratified according to treatment response and ideally also allow treatment response to be predicted. Improved knowledge of molecular pathways and epigenetic mechanisms, including their potential association with environmental influences, will facilitate the discovery of biomarkers that could ultimately be effective tools in clinical practice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject | PHOSPHOLIPASE A(2) ACTIVITY | - |
dc.subject | METHYLOME-WIDE ASSOCIATION | - |
dc.subject | HISTONE DEACETYLASE INHIBITORS | - |
dc.subject | HUMAN CEREBROSPINAL-FLUID | - |
dc.subject | ABERRANT DNA METHYLATION | - |
dc.subject | SUPERIOR TEMPORAL CORTEX | - |
dc.subject | PERIPHERAL-BLOOD CELLS | - |
dc.subject | MEMBRANE-FLUIDITY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.title | Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1080/15622975.2016.1224929 | - |
dc.identifier.wosid | 000404666200002 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.18, no.5, pp.330 - 356 | - |
dc.relation.isPartOf | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 330 | - |
dc.citation.endPage | 356 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject.keywordPlus | PHOSPHOLIPASE A(2) ACTIVITY | - |
dc.subject.keywordPlus | METHYLOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE INHIBITORS | - |
dc.subject.keywordPlus | HUMAN CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | ABERRANT DNA METHYLATION | - |
dc.subject.keywordPlus | SUPERIOR TEMPORAL CORTEX | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD CELLS | - |
dc.subject.keywordPlus | MEMBRANE-FLUIDITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | biomarkers | - |
dc.subject.keywordAuthor | proteomics | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | lipids | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.