Sandcastle Worm-Inspired Blood-Resistant Bone Graft Binder Using a Sticky Mussel Protein for Augmented In Vivo Bone Regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyo Jeong | - |
dc.contributor.author | Choi, Bong-Hyuk | - |
dc.contributor.author | Jun, Sang Ho | - |
dc.contributor.author | Cha, Hyung Joon | - |
dc.date.accessioned | 2021-09-03T15:38:16Z | - |
dc.date.available | 2021-09-03T15:38:16Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12-21 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86511 | - |
dc.description.abstract | Xenogenic bone substitutes are commonly used during orthopedic reconstructive procedures to assist bone regeneration. However, huge amounts of blood accompanied with massive bone loss usually increase the difficulty of placing the xenograft into the bony defect. Additionally, the lack of an organic matrix leads to a decrease in the mechanical strength of the bone-grafted site. For effective bone grafting, this study aims at developing a mussel adhesion-employed bone graft binder with great blood-resistance and enhanced mechanical properties. The distinguishing water (or blood) resistance of the binder originates from sandcastle worm-inspired complex coacervation using negatively charged hyaluronic acid (HA) and a positively charged recombinant mussel adhesive protein (rMAP) containing tyrosine residues. The rMAP/HA coacervate stabilizes the agglomerated bone graft in the presence of blood. Moreover, the rMAP/HA composite binder enhances the mechanical and hemostatic properties of the bone graft agglomerate. These outstanding features improve the osteoconductivity of the agglomerate and subsequently promote in vivo bone regeneration. Thus, the blood-resistant coacervated mussel protein glue is a promising binding material for effective bone grafting and can be successfully expanded to general bone tissue engineering. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TISSUE FACTOR | - |
dc.subject | ADHESION | - |
dc.title | Sandcastle Worm-Inspired Blood-Resistant Bone Graft Binder Using a Sticky Mussel Protein for Augmented In Vivo Bone Regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Sang Ho | - |
dc.identifier.doi | 10.1002/adhm.201601169 | - |
dc.identifier.scopusid | 2-s2.0-85006262106 | - |
dc.identifier.wosid | 000397011200012 | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, v.5, no.24, pp.3191 - 3202 | - |
dc.relation.isPartOf | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.title | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.volume | 5 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 3191 | - |
dc.citation.endPage | 3202 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | TISSUE FACTOR | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordAuthor | blood resistance | - |
dc.subject.keywordAuthor | bone graft binder | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | complex coacervation | - |
dc.subject.keywordAuthor | mussel adhesive protein | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.