Clinical outcome of statin plus ezetimibe versus high-intensity statin therapy in patients with acute myocardial infarction propensity-score matching analysis
DC Field | Value | Language |
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dc.contributor.author | Ji, Mi Seon | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Ahn, Young Keun | - |
dc.contributor.author | Kim, Sang Hyung | - |
dc.contributor.author | Kim, Young Jo | - |
dc.contributor.author | Chae, Shung Chull | - |
dc.contributor.author | Hong, Taek Jong | - |
dc.contributor.author | Seong, In Whan | - |
dc.contributor.author | Chae, Jei Keon | - |
dc.contributor.author | Kim, Chong Jin | - |
dc.contributor.author | Cho, Myeong Chan | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Bae, Jang Ho | - |
dc.contributor.author | Seung, Ki Bae | - |
dc.contributor.author | Park, Seung Jung | - |
dc.date.accessioned | 2021-09-03T15:47:02Z | - |
dc.date.available | 2021-09-03T15:47:02Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12-15 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86532 | - |
dc.description.abstract | Background: It is unclear whether simvastatin-ezetimibe could be an alternative therapy to high-intensity statin therapy in high-risk patients. The aim of this study was to compare the clinical outcomes of simvastatin-ezetimibe and high-intensity statin therapy in patients with acute myocardial infarction (AMI), and especially in those with high-risk factor. Methods: A total of 3520 AMI patients in the KAMIR (Korea Acute Myocardial Infarction Registry) were classified into simvastatin-ezetimibe group (n=1249) and high-intensity statin group (n=2271). Multivariate analysis and propensity-score matching analysis were performed. The primary endpoint was major adverse cardiac events (MACE) at 12-months follow-up. Results: In overall AMI patients, MACE occurred in 116 patients (9.3%) in simvastatin-ezetimibe group and 116 patients (5.1%) in high-intensity statin group. The difference in MACE between groups was driven by repeat revascularization (5.9% vs. 2.2%). After propensity matching analysis, simvastatin-ezetimibe was associated with a higher incidence of MACE than high-intensity statin therapy (adjusted hazard ratio: 3.090, 95% confidence interval: 1.715 to 5.566, p < 0.001). However, in patients with high-risk factors, such as diabetes, old age, or heart failure, simvastatin-ezetimibe had similar incidence of MACE compared with high-intensity statin therapy in further adjusted analysis. Conclusions: In overall AMI patients, high-intensity statin therapy had better clinical outcomes than simvastatin-ezetimibe. However, in patients with high-risk factor, simvastatin-ezetimibe had comparable clinical outcomes to high-intensity statin therapy. Therefore, simvastatin-ezetimibe could be used as an alternative to high-intensity statin therapy in such patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | ACUTE CORONARY SYNDROMES | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | HEART-FAILURE | - |
dc.subject | SECONDARY PREVENTION | - |
dc.subject | COMBINATION THERAPY | - |
dc.subject | OLDER PATIENTS | - |
dc.subject | ATORVASTATIN | - |
dc.subject | MANAGEMENT | - |
dc.subject | STATEMENT | - |
dc.subject | ROSUVASTATIN | - |
dc.title | Clinical outcome of statin plus ezetimibe versus high-intensity statin therapy in patients with acute myocardial infarction propensity-score matching analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.1016/j.ijcard.2016.09.082 | - |
dc.identifier.scopusid | 2-s2.0-84989285863 | - |
dc.identifier.wosid | 000390472000013 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, v.225, pp.50 - 59 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 225 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 59 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROMES | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordPlus | SECONDARY PREVENTION | - |
dc.subject.keywordPlus | COMBINATION THERAPY | - |
dc.subject.keywordPlus | OLDER PATIENTS | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | STATEMENT | - |
dc.subject.keywordPlus | ROSUVASTATIN | - |
dc.subject.keywordAuthor | Ezetimibe simvastatin combination | - |
dc.subject.keywordAuthor | Statins | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
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