The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Jung | - |
dc.contributor.author | Eoh, Kyung Jin | - |
dc.contributor.author | Kim, Lee Kyung | - |
dc.contributor.author | Nam, Eun Ji | - |
dc.contributor.author | Yoon, Sun Och | - |
dc.contributor.author | Kim, Kun-Hong | - |
dc.contributor.author | Lee, Jae Kwan | - |
dc.contributor.author | Kim, Sang Wun | - |
dc.contributor.author | Kim, Young Tae | - |
dc.date.accessioned | 2021-09-03T15:50:07Z | - |
dc.date.available | 2021-09-03T15:50:07Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12-13 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86547 | - |
dc.description.abstract | Recent research has focused on the impact of long noncoding RNA (lncRNA) in cervical carcinogenesis. However, whether HOXA11 antisense (HOXA11-AS) is involved in cervical cancer remains to be elucidated. In the present study, we examined HOXA11-AS expression levels in cervical cancer patients and determined the relationships between HOXA11-AS expression and clinicopathological factors. We also investigated the bio-functional consequences of HOXA11-AS overexpression both in vitro and in vivo. HOXA11-AS expression was significantly greater in tissues from patients with cervical cancer than in control patients (P< 0.001). Multivariate analysis showed that high HOXA11-AS was an independent prognosticator of overall survival (Hazard ratio=2.450, P=0.032). HOXA11-AS overexpression enhanced cell proliferation, migration, and tumor invasion in vitro, whereas HOXA11-AS knockdown inhibited these biologic aggressive features. These adverse changes were accompanied by characteristics of epithelial-mesenchymal transition (EMT). In vivo xenograft experiments using the siHOXA11-AS-transfected HeLa cells revealed that HOXA11-AS strongly induced tumor growth. Furthermore, we found that HOXA11-AS knockdown decreased cancer stemness and triggered the EMT program. In conclusion, HOXA11-AS overexpression correlated with poor survival in patients with cervical cancer. Thus, HOXA11-AS may be a pivotal target for exploring novel cervical cancer therapeutics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | GENE MICROARRAY ANALYSIS | - |
dc.subject | INITIATING CELLS | - |
dc.subject | DNA METHYLATION | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | EXPRESSION | - |
dc.subject | CARCINOMA | - |
dc.subject | GROWTH | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | TRANSCRIPTION | - |
dc.title | The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae Kwan | - |
dc.identifier.doi | 10.18632/oncotarget.12863 | - |
dc.identifier.scopusid | 2-s2.0-85003956480 | - |
dc.identifier.wosid | 000391352800086 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.7, no.50, pp.83001 - 83016 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 7 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 83001 | - |
dc.citation.endPage | 83016 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | GENE MICROARRAY ANALYSIS | - |
dc.subject.keywordPlus | INITIATING CELLS | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordAuthor | HOXA11 antisense | - |
dc.subject.keywordAuthor | long noncoding RNA | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | cervical cancer | - |
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