Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hyunjung | - |
dc.contributor.author | Shin, Ji Hyun | - |
dc.contributor.author | Kim, Eun Sung | - |
dc.contributor.author | Park, So Jung | - |
dc.contributor.author | Bae, Il-Hong | - |
dc.contributor.author | Jo, Yoon Kyung | - |
dc.contributor.author | Jeong, In Young | - |
dc.contributor.author | Kim, Hyoung-June | - |
dc.contributor.author | Lee, Youngjin | - |
dc.contributor.author | Park, Hea Chul | - |
dc.contributor.author | Jeon, Hong Bae | - |
dc.contributor.author | Kim, Ki Woo | - |
dc.contributor.author | Lee, Tae Ryong | - |
dc.contributor.author | Cho, Dong-Hyung | - |
dc.date.accessioned | 2021-09-03T15:51:01Z | - |
dc.date.available | 2021-09-03T15:51:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86552 | - |
dc.description.abstract | The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmental processes in skin, such as keratinocyte differentiation and hair formation. However, the relation between skin pigmentation and primary cilia is largely unknown. Here, we observed that increased melanogenesis in melanocytes treated with a melanogenic inducer was inhibited by a ciliogenesis inducer, cytochalasin D, and serumfree culture. However, these inhibitory effects disappeared in GLI2 knockdown cells. In addition, activation of sonic hedgehog (SHH)-smoothened (Smo) signaling pathway by a Smo agonist, SAG inhibited melanin synthesis in melanocytes and pigmentation in a human skin model. On the contrary, an inhibitor of primary cilium formation, ciliobrevin A1, activated melanogenesis in melanocytes. These results suggest that skin pigmentation may be regulated partly by the induction of ciliogenesis through Smo-GLI2 signaling. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | SONIC HEDGEHOG | - |
dc.subject | INTRAFLAGELLAR TRANSPORT | - |
dc.subject | KIDNEY-DISEASE | - |
dc.subject | MELANOMA-CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | GLI2 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | CILIOGENESIS | - |
dc.subject | HAIR | - |
dc.title | Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hea Chul | - |
dc.identifier.doi | 10.1371/journal.pone.0168025 | - |
dc.identifier.scopusid | 2-s2.0-85006173297 | - |
dc.identifier.wosid | 000392745600047 | - |
dc.identifier.bibliographicCitation | PLoS One, v.11, no.12 | - |
dc.relation.isPartOf | PLoS One | - |
dc.citation.title | PLoS One | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SONIC HEDGEHOG | - |
dc.subject.keywordPlus | INTRAFLAGELLAR TRANSPORT | - |
dc.subject.keywordPlus | KIDNEY-DISEASE | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GLI2 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CILIOGENESIS | - |
dc.subject.keywordPlus | HAIR | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.