Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
DC Field | Value | Language |
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dc.contributor.author | Chin, Sang Ouk | - |
dc.contributor.author | Rhee, Sang Youl | - |
dc.contributor.author | Chon, Suk | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Park, Yongsoo | - |
dc.contributor.author | Nam, Moon Suk | - |
dc.contributor.author | Lee, Kwan Woo | - |
dc.contributor.author | Chun, Ki Hong | - |
dc.contributor.author | Woo, Jeong-taek | - |
dc.contributor.author | Kim, Young Seol | - |
dc.date.accessioned | 2021-09-03T16:08:26Z | - |
dc.date.available | 2021-09-03T16:08:26Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86626 | - |
dc.description.abstract | Aim: Although hypoglycemia is associated with cognitive dysfunction, including dementia, in patients with type 2 diabetes mellitus (DM), the data are equivocal. The purpose of this study was to investigate the association between hypoglycemia, dementia, and other cognitive dysfunctions. Methods: This was a prospective observational study based upon the Korea National Diabetes Program (KNDP). Among the 4540 participants in the KNDP cohort, individuals aged >= 60 years without any history of hypoglycemia or cognitive dysfunction (n = 1957) were included. Nationally representative data from the Health Insurance Review and Assessment Service of Korea claim database were used to obtain a more precise determination of patient outcome. Results: During a mean follow-up period of 3.4 +/- 0.9 years, 118 subjects experienced hypoglycemia-related events. The incidence of dementia and cognitive dysfunction was 7.5 cases per 1000 person-years (PY) and 0.61 cases per 1000 PY, respectively. In the subjects who experienced hypoglycemic events (relative to those who did not), the incidence of dementia was significantly higher (P = 0.0139), but the incidence of cognitive dysfunction was not (P = 0.1106). Hypoglycemic events were associated with dementia (HR, 2.689; 95% CI, 1.080-6.694, P = 0.0335) following multiple adjustments. There was also a significant linear trend toward an increased dementia risk commensurate with an increasing number of hypoglycemic events (P = 0.0286). Conclusions: Hypoglycemia is significantly associated with the risk of dementia in Korean type 2 DM patients aged >= 60 years. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | ANGIOTENSIN-CONVERTING ENZYME | - |
dc.subject | COGNITIVE FUNCTION | - |
dc.subject | RISK | - |
dc.subject | SULFONYLUREAS | - |
dc.subject | HYPERGLYCEMIA | - |
dc.subject | PERFORMANCE | - |
dc.subject | IMPAIRMENT | - |
dc.subject | CHILDREN | - |
dc.subject | GLUCOSE | - |
dc.subject | ADULTS | - |
dc.title | Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.identifier.doi | 10.1016/j.diabres.2016.09.027 | - |
dc.identifier.scopusid | 2-s2.0-84993967668 | - |
dc.identifier.wosid | 000390463200007 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, v.122, pp.54 - 61 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.title | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.volume | 122 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 61 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ANGIOTENSIN-CONVERTING ENZYME | - |
dc.subject.keywordPlus | COGNITIVE FUNCTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SULFONYLUREAS | - |
dc.subject.keywordPlus | HYPERGLYCEMIA | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordAuthor | Hypoglycemia | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
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