Association between functional NLRP3 polymorphisms and susceptibility to autoimmune and inflammatory diseases: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S-C | - |
dc.date.accessioned | 2021-09-03T16:12:32Z | - |
dc.date.available | 2021-09-03T16:12:32Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86650 | - |
dc.description.abstract | Objective This study determined whether NLRP3 polymorphisms rs35829419 C/A and rs10754558 C/G were associated with autoimmune and inflammatory diseases. Methods An association between the NLRP3 rs35829419 C/A and rs10754558 C/G polymorphisms and autoimmune and inflammatory diseases was determined by performing a meta-analysis by using (1) allele contrast, (2) recessive, (3) dominant, and (4) co-dominant models. Results Thirty comparative studies involving 8069 patients and 8824 controls were included in the meta-analysis. No association was observed between autoimmune and inflammatory diseases and NLRP3 rs35829419 C allele (OR=1.020, 95% CI=0.804-1.295, p=0.869). Stratification by ethnicity showed no association between the NLRP3 rs35829419 C allele and autoimmune and inflammatory diseases in European, Latin American, and Polynesian populations. Stratification by disease type showed no association between the NLRP3 rs35829419 C allele and gout, SLE, RA, celiac disease, and Crohn's disease. Moreover, no association was observed between autoimmune and inflammatory diseases and the NLRP3 rs10754558 C allele (OR=1.057, 95% CI=0.950-1.177, p=0.310). However, stratification by ethnicity showed an association between the NLRP3 rs10754558 C allele and autoimmune and inflammatory diseases in the Latin American (OR=1.399, 95% CI=1.201-1.630, p=1.6x10(-6)) but not in European and Asian populations. Further, stratification by disease type showed a significant association of the NLRP3 rs10754558 C allele with SLE (OR=1.465 95% CI=1.144-1.875, p=0.002) but not with gout and celiac disease. The same pattern was observed for the NLRP3 rs10754558 C allele in the recessive model. Conclusions Our results indicated that the NLRP3 rs10754558 C/G polymorphism was associated with susceptibility to SLE and with autoimmune and inflammatory diseases in Latin American individuals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | CROHNS-DISEASE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | CELIAC-DISEASE | - |
dc.subject | PRIMARY GOUT | - |
dc.subject | ACTIVATION | - |
dc.subject | CARD8 | - |
dc.subject | POPULATION | - |
dc.subject | PREDISPOSITION | - |
dc.title | Association between functional NLRP3 polymorphisms and susceptibility to autoimmune and inflammatory diseases: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1177/0961203316644336 | - |
dc.identifier.scopusid | 2-s2.0-84994181511 | - |
dc.identifier.wosid | 000387447700006 | - |
dc.identifier.bibliographicCitation | LUPUS, v.25, no.14, pp.1558 - 1566 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1558 | - |
dc.citation.endPage | 1566 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | CELIAC-DISEASE | - |
dc.subject.keywordPlus | PRIMARY GOUT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CARD8 | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PREDISPOSITION | - |
dc.subject.keywordAuthor | Autoimmune diseases | - |
dc.subject.keywordAuthor | NLRP3 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
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