Fatal Graft-Versus-Host Disease Following Adult-To-Adult Living Donor Liver Transplantation From an HLA Nonhomozygous Donor
DC Field | Value | Language |
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dc.contributor.author | Yu, Young-Dong | - |
dc.contributor.author | Kim, Dong-Sik | - |
dc.contributor.author | Ha, Neul | - |
dc.contributor.author | Jung, Sung-Won | - |
dc.contributor.author | Han, Jae-Hyun | - |
dc.contributor.author | Kim, Joo-Young | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Cho, Yun-Jung | - |
dc.date.accessioned | 2021-09-03T16:17:49Z | - |
dc.date.available | 2021-09-03T16:17:49Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1526-9248 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86678 | - |
dc.description.abstract | The use of a human leukocyte antigen (HLA) homozygous donor to a haploidentical recipient is a well-documented cause of transfusion-associated graft-versus-host disease (GVHD). Several authors have reported that use of a graft from an HLA-homozygous donor with 1-way donor-recipient HLA matching led to an extremely high risk of developing GVHD in LDLT. We have experienced a fatal case of acute GVHD following adult-to-adult LDLT from a donor who was heterozygous at a single HLA locus. A 53-year-old female underwent LDLT for chronic hepatitis B and recurrent hepatocellular carcinoma. The donor was her 23-year-old son. The HLA phenotype of the donor was not homozygous (A24, -; B54, -; DR4, 9) and revealed one-way donor-dominant HLA matching at two loci with the recipient (A2, 24; B48, 54; DR4, 12). On the fortieth postoperative day, the patient showed erythematous skin lesions. Skin biopsy revealed typical findings of GVHD. Donor-derived chimerism was demonstrated by performing fluorescent in situ hybridization (FISH) using the recipient's skin tissue. As the clinical course deteriorated, etanercept was started in addition to broad-spectrum antibiotics but there was no improvement. As multi-organ failure progressed, the patient succumbed to death on the 54th postoperative day, which was 2 weeks after onset of GVHD. The prevention of GVHD is more important since the results of treatment have been disappointing. We have experienced a fatal case of acute GVHD following adult-to-adult LDLT from a HLA non-homozygous donor. HLA heterozygosity at a single locus does not preclude the possibility of developing GVHD following adult-to-adult LDLT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Fatal Graft-Versus-Host Disease Following Adult-To-Adult Living Donor Liver Transplantation From an HLA Nonhomozygous Donor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Young-Dong | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Sik | - |
dc.contributor.affiliatedAuthor | Cho, Yun-Jung | - |
dc.identifier.doi | 10.1177/1526924816664087 | - |
dc.identifier.scopusid | 2-s2.0-85014310748 | - |
dc.identifier.wosid | 000388855800019 | - |
dc.identifier.bibliographicCitation | PROGRESS IN TRANSPLANTATION, v.26, no.4, pp.394 - 396 | - |
dc.relation.isPartOf | PROGRESS IN TRANSPLANTATION | - |
dc.citation.title | PROGRESS IN TRANSPLANTATION | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 394 | - |
dc.citation.endPage | 396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordAuthor | graft-versus-host disease | - |
dc.subject.keywordAuthor | living donor liver transplantation | - |
dc.subject.keywordAuthor | human leukocyte antigen | - |
dc.subject.keywordAuthor | nonhomozygous | - |
dc.subject.keywordAuthor | transplant donor | - |
dc.subject.keywordAuthor | related body regions | - |
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