Foeniculum vulgare Mill. increases cytosolic Ca2+ concentration and inhibits store-operated Ca2+ entry in vascular endothelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, A. Young | - |
dc.contributor.author | Lee, Hui Su | - |
dc.contributor.author | Seol, Geun Hee | - |
dc.date.accessioned | 2021-09-03T16:19:09Z | - |
dc.date.available | 2021-09-03T16:19:09Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86685 | - |
dc.description.abstract | This study assessed the effects of essential oil of Foeniculum vulgare Mill. (fennel oil) and of transanethole, the main component of fennel oil, on extracellular Ca2+-induced store-operated Ca2+ entry (SOCE) into vascular endothelial (EA) cells and their mechanisms of action. Components of fennel oil were analyzed by gas chromatography-mass spectrometry. Cytosolic Ca2+ concentration ([Ca2+](c)) in EA cells was determined using Fura-2 fluorescence. In the presence of extracellular Ca2+, fennel oil significantly increased [Ca2+](c) in EA cells; this increase was significantly inhibited by the Ca2+ channel blockers La3+ and nifedipine. In contrast, fennel oil induced [Ca2+](c) was significantly lower in Ca2+-free solution, suggesting that fennel oil increases [Ca2+](c) mainly by enhancing Ca2+ influx into EA cells. [Ca2+](c) mobilization by trans-anethole was similar to that of fennel oil. Moreover, SOCE was suppressed by fennel oil and trans-anethole. SOCE was also attenuated by lanthanum (La3+), a non-selective cation channel (NSC) blocker; 2-aminoethoxydiphenyl borane (2-APB), an inositol 1,4,5-triphosphate (IP3) receptor inhibitor and SOCE blocker; and U73122, an inhibitor of phospholipase C (PLC). Further, SOCE was more strongly inhibited by La3+ plus fennel oil or trans-anethole than by La3+ alone. These findings suggest that fennel oil and trans-anethole significantly inhibit SOCE-induced [Ca2+] c increase in vascular endothelial cells and that these reactions may be mediated by NSC, IP3-dependent Ca2+ mobilization, and PLC activation. (C) 2016 Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | ACUTE LUNG INJURY | - |
dc.subject | ESSENTIAL OIL | - |
dc.subject | CALCIUM-ENTRY | - |
dc.subject | CHANNELS | - |
dc.subject | ANETHOLE | - |
dc.subject | PROTECTS | - |
dc.subject | RECEPTOR | - |
dc.subject | RELEASE | - |
dc.title | Foeniculum vulgare Mill. increases cytosolic Ca2+ concentration and inhibits store-operated Ca2+ entry in vascular endothelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, A. Young | - |
dc.contributor.affiliatedAuthor | Seol, Geun Hee | - |
dc.identifier.doi | 10.1016/j.biopha.2016.10.013 | - |
dc.identifier.scopusid | 2-s2.0-84990933988 | - |
dc.identifier.wosid | 000390438100092 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.84, pp.800 - 805 | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 84 | - |
dc.citation.startPage | 800 | - |
dc.citation.endPage | 805 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | CALCIUM-ENTRY | - |
dc.subject.keywordPlus | CHANNELS | - |
dc.subject.keywordPlus | ANETHOLE | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | Foeniculum vulgare Mill. | - |
dc.subject.keywordAuthor | trans-anethole | - |
dc.subject.keywordAuthor | Store-operated Ca2+ entry | - |
dc.subject.keywordAuthor | Cytosolic Ca2+ | - |
dc.subject.keywordAuthor | Vascular endothelial cells | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.