Gr-1(int)CD11b(+) myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival
DC Field | Value | Language |
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dc.contributor.author | Choi, Wungrak | - |
dc.contributor.author | Ji, Yong Woo | - |
dc.contributor.author | Ham, Hwa-Yong | - |
dc.contributor.author | Yeo, Areum | - |
dc.contributor.author | Noh, Hyemi | - |
dc.contributor.author | Jin, Su-Eon | - |
dc.contributor.author | Song, Jong Suk | - |
dc.contributor.author | Kim, Hyeon Chang | - |
dc.contributor.author | Kim, Eung Kwon | - |
dc.contributor.author | Lee, Hyung Keun | - |
dc.date.accessioned | 2021-09-03T16:34:27Z | - |
dc.date.available | 2021-09-03T16:34:27Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86770 | - |
dc.description.abstract | We identified the characteristics of myeloid-derived suppressor cells (MDSCs) and investigated their mechanism of induction and their functional role in allograft rejection using a murine corneal allograft model. In mice, MDSCs coexpress CD11b and myeloid differentiation antigen Gr-1.Gr-1(+)CD11b(+) cells infiltrated allografted corneas between 4 d and 4 wk after surgery; however, the frequencies of Gr-1(+)CD11b(+) cells were not different between accepted and rejected allografts or in peripheral blood or BM. Of interest, Gr-1(int)CD11b(+) cells, but not Gr-1(hi)CD11b(+) cells, infiltrated the accepted graft early after surgery and expressed high levels of immunosuppressive cytokines, including IL-10, TGF-beta, and TNF-related apoptosis-inducing ligand. This population remained until 4 wk after surgery. In vitro, only high dose (>100 ng/ml) of IFN-gamma plus GM-CSF could induce immunosuppressive cytokine expression in Gr-1(int)CD11b(+) cells. Furthermore, adoptive transfer of Gr-1(int)CD11b(+) cells reduced T cell infiltration, which improved graft survival. In conclusion, high-dose IFN-gamma in allograft areas is essential for development of Gr-1(int)CD11b(+) MDSCs in corneal allografts, and subtle environmental changes in the early period of the allograft can result in a large difference in graft survival. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject | IFN-GAMMA | - |
dc.subject | IMMUNE PRIVILEGE | - |
dc.subject | MICE LACKING | - |
dc.subject | REJECTION | - |
dc.subject | EXPRESSION | - |
dc.subject | TRAIL | - |
dc.subject | ALLOSENSITIZATION | - |
dc.subject | TRANSPLANTATION | - |
dc.title | Gr-1(int)CD11b(+) myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Jong Suk | - |
dc.identifier.doi | 10.1189/jlb.5A1115-508RR | - |
dc.identifier.scopusid | 2-s2.0-85003015154 | - |
dc.identifier.wosid | 000388593000023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.100, no.6, pp.1453 - 1463 | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 100 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1453 | - |
dc.citation.endPage | 1463 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | IMMUNE PRIVILEGE | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | REJECTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRAIL | - |
dc.subject.keywordPlus | ALLOSENSITIZATION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordAuthor | keratoplasty | - |
dc.subject.keywordAuthor | myeloid differentiation antigen Gr-1 | - |
dc.subject.keywordAuthor | interferon-gamma (IFN-gamma) | - |
dc.subject.keywordAuthor | TNF-related apoptosis-inducing ligand (TRAIL) | - |
dc.subject.keywordAuthor | adoptive transfer | - |
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