Viral Inhibition of PRR-Mediated Innate Immune Response: Learning from KSHV Evasion Strategies
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye-Ra | - |
dc.contributor.author | Choi, Un Yung | - |
dc.contributor.author | Hwang, Sung-Woo | - |
dc.contributor.author | Kim, Stephanie | - |
dc.contributor.author | Jung, Jae U. | - |
dc.date.accessioned | 2021-09-03T16:38:24Z | - |
dc.date.available | 2021-09-03T16:38:24Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-11-30 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86791 | - |
dc.description.abstract | The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activities for their benefit. In particular, due to the potent antiviral activities of IFN and cytokines, viruses have developed various strategies to meticulously modulate intracellular innate immune sensing mechanisms to facilitate efficient viral replication and persistence. In this review, we highlight recent advances in the study of viral immune evasion strategies with a specific focus on how Kaposi's sarcoma-associated herpesvirus (KSHV) effectively targets host PRR signaling pathways. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | SARCOMA-ASSOCIATED-HERPESVIRUS | - |
dc.subject | DOUBLE-STRANDED-RNA | - |
dc.subject | CYTOSOLIC DNA SENSOR | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | GMP-AMP SYNTHASE | - |
dc.subject | RIG-I | - |
dc.subject | KAPOSI-SARCOMA | - |
dc.subject | PATTERN-RECOGNITION | - |
dc.subject | TRANSCRIPTION ACTIVATOR | - |
dc.subject | PATHOGEN RECOGNITION | - |
dc.title | Viral Inhibition of PRR-Mediated Innate Immune Response: Learning from KSHV Evasion Strategies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Ra | - |
dc.identifier.doi | 10.14348/molcells.2016.0232 | - |
dc.identifier.scopusid | 2-s2.0-85017180473 | - |
dc.identifier.wosid | 000389530800001 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.39, no.11, pp.777 - 782 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 39 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 777 | - |
dc.citation.endPage | 782 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002170068 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | SARCOMA-ASSOCIATED-HERPESVIRUS | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | CYTOSOLIC DNA SENSOR | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | GMP-AMP SYNTHASE | - |
dc.subject.keywordPlus | RIG-I | - |
dc.subject.keywordPlus | KAPOSI-SARCOMA | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION | - |
dc.subject.keywordPlus | TRANSCRIPTION ACTIVATOR | - |
dc.subject.keywordPlus | PATHOGEN RECOGNITION | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | KSHV | - |
dc.subject.keywordAuthor | immune evasion strategy | - |
dc.subject.keywordAuthor | innate immune response | - |
dc.subject.keywordAuthor | PRRs | - |
dc.subject.keywordAuthor | type I IFN | - |
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