Soluble gamma c cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus
DC Field | Value | Language |
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dc.contributor.author | Park, Joo-Young | - |
dc.contributor.author | Jo, Yuna | - |
dc.contributor.author | Ko, Eunhee | - |
dc.contributor.author | Luckey, Megan A. | - |
dc.contributor.author | Park, Yoo Kyoung | - |
dc.contributor.author | Park, Se-Ho | - |
dc.contributor.author | Park, Jung-Hyun | - |
dc.contributor.author | Hong, Changwan | - |
dc.date.accessioned | 2021-09-03T16:59:14Z | - |
dc.date.available | 2021-09-03T16:59:14Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-11-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86837 | - |
dc.description.abstract | The soluble gamma c protein (s gamma c) is a naturally occurring splice isoform of the gamma c cytokine receptor that is produced by activated T cells and inhibits gamma c cytokine signaling. Here we show that s gamma c expression is also highly upregulated in immature CD4(+)CD8(+) thymocytes but then downregulated in mature thymocytes. These results indicate a developmentally controlled mechanism for s gamma c expression and suggest a potential role for s gamma c in regulating T cell development in the thymus. Indeed, s gamma c overexpression resulted in significantly reduced thymocyte numbers and diminished expansion of immature thymocytes, concordant to its role in suppressing signaling by IL-7, a critical gamma c cytokine in early thymopoiesis. Notably, s gamma c overexpression also impaired generation of iNKT cells, resulting in reduced iNKT cell percentages and numbers in the thymus. iNKT cell development requires IL-15, and we found that s gamma c interfered with IL-15 signaling to suppress iNKT cell generation in the thymus. Thus, s gamma c represents a new mechanism to control cytokine availability during T cell development that constrains mature T cell production and specifically iNKT cell generation in the thymus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | DOUBLE-POSITIVE THYMOCYTES | - |
dc.subject | FUNCTIONALLY DISTINCT SUBSETS | - |
dc.subject | T-CELLS | - |
dc.subject | NATURAL-KILLER | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | LINEAGE FATE | - |
dc.subject | TERMINAL MATURATION | - |
dc.subject | HOMEOSTASIS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | CHAIN | - |
dc.title | Soluble gamma c cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.1038/srep36962 | - |
dc.identifier.scopusid | 2-s2.0-84994888523 | - |
dc.identifier.wosid | 000387550900001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DOUBLE-POSITIVE THYMOCYTES | - |
dc.subject.keywordPlus | FUNCTIONALLY DISTINCT SUBSETS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | NATURAL-KILLER | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | LINEAGE FATE | - |
dc.subject.keywordPlus | TERMINAL MATURATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CHAIN | - |
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