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Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model

Authors
Park, Jang WonYun, Young-PilPark, KyeongsoonLee, Jae YongKim, Hak-JunKim, Sung EunSong, Hae-Ryong
Issue Date
1-11월-2016
Publisher
ELSEVIER
Keywords
Ibuprofen; PLGA; Porous microspheres; Anti-inflammatory effect; Osteoarthritis
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v.147, pp.265 - 273
Indexed
SCIE
SCOPUS
Journal Title
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume
147
Start Page
265
End Page
273
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/86891
DOI
10.1016/j.colsurfb.2016.07.050
ISSN
0927-7765
Abstract
The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model. A dose-dependent in vitro anti-inflammatory effect on pro-inflammatory cytokine markers (matrix metallopeptidase-3 (MMP-3), matrix metallopeptidase-13 (MMP-13), cyclooxygenase-2 (COX-2), a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), interleukin-6 (IL-6), and tumor necrosis factor (TNF-alpha) was observed by confirming with real-time PCR analyses. In vivo, treatment with IBU/PMSs reduced MIA-stimulated mRNA expression of MMP-3, MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-alpha in rat synoviocytes. In addition, we demonstrated that intra-articular IBLI/PMSs suppressed the progression of MIA-induced OA in the rat model via anti-inflammatory mechanisms. In conclusion, IBU/PMSs are a promising therapeutic material to control the pain and progression of OA. (C) 2016 Elsevier B.V. All rights reserved.
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