Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Clinical significance of radiotherapy in patients with primary uterine carcinosarcoma: a multicenter retrospective study (KROG 13-08)

Authors
Cha, JihyeKim, Young SeokPark, WonKim, Hak JaeKim, Joo-YoungKim, Jin HeeKim, JureeYoon, Won SupKim, Jun WonKim, Yong Bae
Issue Date
11월-2016
Publisher
KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
Keywords
Locoregional Control; Radiotherapy; Adjuvant; Uterine Carcinosarcoma
Citation
JOURNAL OF GYNECOLOGIC ONCOLOGY, v.27, no.6
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF GYNECOLOGIC ONCOLOGY
Volume
27
Number
6
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87032
DOI
10.3802/jgo.2016.27.e58
ISSN
2005-0380
Abstract
Objective: To investigate the role of radiotherapy (RT) in patients who underwent hysterectomy for uterine carcinosarcoma (UCS). Methods: Patients with the International Federation of Gynecology and Obstetrics stage IIVa UCS who were treated between 1990 and 2012 were identified retrospectively in a multiinstitutional database. Of 235 identified patients, 97 (41.3%) received adjuvant RT. Twentytwo patients with a history of previous pelvic RT were analyzed separately. Survival outcomes were assessed using the Kaplan-Meier method and Cox proportional hazards model. Results: Patients with a previous history of pelvic RT had poor survival outcomes, and 72.6% of these patients experienced locoregional recurrence; however, none received RT after a diagnosis of UCS. Univariate analyses revealed that pelvic lymphadenectomy (PLND) and para-aortic lymph node sampling were significant factors for locoregional recurrence-free survival (LRRFS) and disease-free survival (DFS). Among patients without previous pelvic RT, the percentage of locoregional failure was lower for those who received adjuvant RT than for those who did not (28.5% vs. 17.5%, p= 0.107). Multivariate analysis revealed significant correlations between PLND and LRRFS, distant metastasis-free survival, and DFS. In subgroup analyses, RT significantly improved the 5-year LRRFS rate of patients who did not undergo PLND (52.7% vs. 18.7% for non-RT, p< 0.001). Conclusion: Adjuvant RT decreased the risk of locoregional recurrence after hysterectomy for UCS, particularly in patients without surgical nodal staging. Given the poorer locoregional outcomes of patients previously subjected to pelvic RT, meticulous re-administration of RT might improve locoregional control while leading to less toxicity in these patients.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE