Association between the three functional miR-146a single-nucleotide polymorphisms, rs2910164, rs57095329, and rs2431697, and autoimmune disease susceptibility: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Robin | - |
dc.contributor.author | Lee, Won Jin | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.date.accessioned | 2021-09-03T17:40:01Z | - |
dc.date.available | 2021-09-03T17:40:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0891-6934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87039 | - |
dc.description.abstract | Studies suggest associations between the miR-146a single nucleotide polymorphisms (SNPs) and susceptibility to autoimmune diseases. However, the results are inconsistent and inconclusive. Therefore, the aim of this study was to arrive at a conclusion about the association between the three functional miR-146a SNPs and autoimmune disease risk. Studies were identified through PubMed/MEDLINE searches for studies published up to January 2016 using as keywords rs2910164, rs57095329, rs2431697, and miR-146a polymorphisms. Thirty studies were included in the meta-analysis. The SNP rs2910164 G>C was found to be associated with increased risk of multiple sclerosis (CC + CG versus GG, OR = 1.25, 95% CI: 1.01-1.55), with decreased risks of psoriasis (C versus G, OR = 0.81, 95% CI: 0.69-0.96; CC versus GC + GG, OR = 0.73, 95% CI: 0.56-0.94), Behcet's disease (CC versus GC + GG, OR = 0.60, 95% CI: 0.50-0.73), asthma (C versus G, OR = 0.80, 95% CI: 0.69-0.93; CC versus GC + GG, OR = 0.65, 95% CI: 0.48-0.86), and uveitis (CC + CG versus GG, OR = 0.61, 95% CI: 0.49-0.77). The SNP rs2431697 C>T was found to be associated with an increased risk of SLE (T versus C, OR = 1.26, 95% CI: 1.15-1.38; TC + TT versus CC, OR = 1.28, 95% CI: 1.03-1.58; TT versus TC + CC, OR = 1.40, 95% CI: 1.21-1.62). The SNP rs57095329 A>G was found to be associated with an increased risk of SLE (G versus C, OR = 1.25, 95% CI: 1.17-1.35). The miR-146a SNPs rs2910164, rs57095329, rs2431697 are associated with susceptibility to certain autoimmune diseases. However, for other autoimmune diseases, they may be protective or insignificant. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | MULTIPLE-SCLEROSIS SUSCEPTIBILITY | - |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject | ETS-1 GENE POLYMORPHISMS | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | CHINESE POPULATION | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | KINASE IRAK1 | - |
dc.title | Association between the three functional miR-146a single-nucleotide polymorphisms, rs2910164, rs57095329, and rs2431697, and autoimmune disease susceptibility: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.identifier.doi | 10.3109/08916934.2016.1171854 | - |
dc.identifier.scopusid | 2-s2.0-84964413006 | - |
dc.identifier.wosid | 000388765700002 | - |
dc.identifier.bibliographicCitation | AUTOIMMUNITY, v.49, no.7, pp.451 - 458 | - |
dc.relation.isPartOf | AUTOIMMUNITY | - |
dc.citation.title | AUTOIMMUNITY | - |
dc.citation.volume | 49 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 458 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS SUSCEPTIBILITY | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | ETS-1 GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | CHINESE POPULATION | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | KINASE IRAK1 | - |
dc.subject.keywordAuthor | Autoimmunity | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | miR-146a | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | susceptibility | - |
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