Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4(+) T cells through the modulation of mitogen-activated protein kinases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eunchong | - |
dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Park, Su-Ho | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-03T17:45:26Z | - |
dc.date.available | 2021-09-03T17:45:26Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87068 | - |
dc.description.abstract | CD4(+) T cell activation and adequate differentiation into effector T helper (Th) cells are crucial for mediating adaptive immune responses to cope with foreign pathogens. Despite the significant role of Th cells, excessive increases in their numbers result in inflammatory and autoimmune diseases. In this study, we investigated the effects of costunolide, a plant-derived natural compound with an anti-inflammatory activity, in regulating Th cells and the underlying mechanisms. Costunolide significantly decreased cell populations of differentiated Th1, Th2, and Th17 subsets under Th subset-polarizing conditions, while exerting statistically negligible effects on Treg cell differentiation. Furthermore, costunolide inhibited the expression level of Th subset-polarizing master genes such as T-bet, GATA3, and ROR-gamma t, indicating that costunolide inhibits the differentiation of CD4(+) T cells into Th subsets. Additionally, costunolide suppressed the proliferative activity of CD4(+) T cells and the expression of CD69 activation marker on CD4(+) T cells. When the molecular targets of costunolide were investigated, phosphorylation of ERK and p38 was found to be decreased under Th subset-polarizing conditions, whereas activity of JNK remained unchanged. U0126, an ERIC inhibitor, and SB203580, a p38 inhibitor, decreased the expression of CD69 upon TCR stimulation and inhibited CD4(+) T cell differentiation, indicating that both ERK and p38 are suggested to be critical molecular targets of costunolide. Taken together, these results suggest that costunolide inhibits the differentiation of CD4(+) T cells by suppressing ERIC and p38 activities and can be an effective therapeutic agent for T cell-mediated immune diseases. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | TH17 CELLS | - |
dc.subject | STEM BARK | - |
dc.subject | P38 MAPK | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | EXPRESSION | - |
dc.subject | ASTHMA | - |
dc.title | Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4(+) T cells through the modulation of mitogen-activated protein kinases | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.intimp.2016.10.006 | - |
dc.identifier.scopusid | 2-s2.0-84991759033 | - |
dc.identifier.wosid | 000389087500063 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.40, pp.508 - 516 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 40 | - |
dc.citation.startPage | 508 | - |
dc.citation.endPage | 516 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | STEM BARK | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordAuthor | Costunolide | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | T cell differentiation | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | p38 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.