The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | Hong, Su Jin | - |
dc.contributor.author | Park, Soo-Heon | - |
dc.contributor.author | Moon, Jeong Seop | - |
dc.contributor.author | Shin, Woon Geon | - |
dc.contributor.author | Kim, Jae Gyu | - |
dc.contributor.author | Lee, Yong Chan | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Jae J. | - |
dc.contributor.author | Lee, Hang-Lak | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.contributor.author | Hwangbo, Young | - |
dc.contributor.author | Xu, Jianming | - |
dc.contributor.author | Wang, Bangmao | - |
dc.contributor.author | Xue, Zhanxiong | - |
dc.contributor.author | Liu, Fei | - |
dc.contributor.author | Yuan, Yaozong | - |
dc.contributor.author | Leelakusolvong, Somchai | - |
dc.contributor.author | Dy, Frederick | - |
dc.date.accessioned | 2021-09-03T18:00:52Z | - |
dc.date.available | 2021-09-03T18:00:52Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87123 | - |
dc.description.abstract | Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1 +/- 13.8 in the combination therapy group and -15.1 +/- 11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4 +/- 6.6 in the combination therapy group and -6.8 +/- 5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | PROTON PUMP INHIBITOR | - |
dc.subject | GASTROESOPHAGEAL-REFLUX | - |
dc.subject | BARRETTS-ESOPHAGUS | - |
dc.subject | EROSIVE ESOPHAGITIS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | FREE-RADICALS | - |
dc.subject | BILE-ACIDS | - |
dc.subject | DISEASE | - |
dc.subject | GASTRITIS | - |
dc.subject | RATS | - |
dc.title | The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang Woo | - |
dc.identifier.doi | 10.5009/gnl15537 | - |
dc.identifier.scopusid | 2-s2.0-84992602775 | - |
dc.identifier.wosid | 000386644900010 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.10, no.6, pp.910 - 916 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 910 | - |
dc.citation.endPage | 916 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002164932 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | PROTON PUMP INHIBITOR | - |
dc.subject.keywordPlus | GASTROESOPHAGEAL-REFLUX | - |
dc.subject.keywordPlus | BARRETTS-ESOPHAGUS | - |
dc.subject.keywordPlus | EROSIVE ESOPHAGITIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | BILE-ACIDS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GASTRITIS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Peptic esophagitis | - |
dc.subject.keywordAuthor | Symptoms | - |
dc.subject.keywordAuthor | Heartburn | - |
dc.subject.keywordAuthor | Rebamipide | - |
dc.subject.keywordAuthor | Esomeprazole | - |
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