L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial
DC Field | Value | Language |
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dc.contributor.author | An, Jee Hyun | - |
dc.contributor.author | Kim, Yoon Jung | - |
dc.contributor.author | Kim, Kyeong Jin | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Kim, Nam Hoon | - |
dc.contributor.author | Kim, Hee Young | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.date.accessioned | 2021-09-03T18:08:59Z | - |
dc.date.available | 2021-09-03T18:08:59Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10-20 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87157 | - |
dc.description.abstract | Hypothyroid patients experience fatigue-related symptoms despite adequate thyroid hormone replacement. Thyroid hormone plays an essential role in carnitine-dependent fatty acid import and oxidation. We investigated the effects of L-carnitine supplementation on fatigue in patients with hypothyroidism. In total, 60 patients (age 50.0 +/- 9.2 years, 3 males, 57 females) who still experienced fatigue (fatigue severity scale [FSS] score >= 36) were given L-carnitine (n = 30, 990 mg L-carnitine twice daily) or placebo (n = 30) for 12 weeks. After 12 weeks, although neither the FSS score nor the physical fatigue score (PFS) changed significantly, the mental fatigue score (MFS) was significantly decreased by treatment with L-carnitine compared with placebo (from 4.5 +/- 1.9 to 3.9 +/- 1.5 vs. from 4.2 +/- 1.8 to 4.6 +/- 1.6, respectively; P < 0.01). In the L-carnitine group, 75.0%, 53.6%, and 50.0% of patients showed improvement in the FSS score, PFS, and MPS, respectively, but only 20.0%, 24.0%, and 24.0%, respectively, did so in the placebo group (all P < 0.05). Both the PFS and MFS were significantly improved in patients younger than 50 years and those with free T3 >= 4.0 pg/mL by treatment with L-carnitine compared with placebo. Additionally, the MFS was significantly improved in patients taking thyroid hormone after thyroid cancer surgery. These results suggest that L-carnitine supplementation may be useful in alleviating fatigue symptoms in hypothyroid patients, especially in those younger than 50 years and those who have hypothyroidism after thyroidectomy for thyroid cancer (ClinicalTrials.gov: NCT01769157). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPAN ENDOCRINE SOC | - |
dc.subject | CONTROLLED CLINICAL-TRIAL | - |
dc.subject | THYROID-HORMONE | - |
dc.subject | HEMODIALYSIS-PATIENTS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | PHASE-III | - |
dc.subject | DISEASE | - |
dc.subject | METABOLISM | - |
dc.subject | PALMITOYLTRANSFERASE | - |
dc.subject | HYPERTHYROIDISM | - |
dc.subject | INCREASES | - |
dc.title | L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.identifier.doi | 10.1507/endocrj.EJ16-0109 | - |
dc.identifier.scopusid | 2-s2.0-84993964510 | - |
dc.identifier.wosid | 000386540100003 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, v.63, no.10, pp.885 - 895 | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.citation.title | ENDOCRINE JOURNAL | - |
dc.citation.volume | 63 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 885 | - |
dc.citation.endPage | 895 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CONTROLLED CLINICAL-TRIAL | - |
dc.subject.keywordPlus | THYROID-HORMONE | - |
dc.subject.keywordPlus | HEMODIALYSIS-PATIENTS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PHASE-III | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PALMITOYLTRANSFERASE | - |
dc.subject.keywordPlus | HYPERTHYROIDISM | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordAuthor | L-carnitine | - |
dc.subject.keywordAuthor | Hypothyroidism | - |
dc.subject.keywordAuthor | Fatigue | - |
dc.subject.keywordAuthor | Fatigue scale | - |
dc.subject.keywordAuthor | Wessely and Powell score | - |
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