Isonitrile as an Ultrasensitive Infrared Reporter of Hydrogen-Bonding Structure and Dynamics
DC Field | Value | Language |
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dc.contributor.author | Maj, Michal | - |
dc.contributor.author | Ahn, Changwoo | - |
dc.contributor.author | Blasiak, Bartosz | - |
dc.contributor.author | Kwak, Kyungwon | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.date.accessioned | 2021-09-03T18:51:36Z | - |
dc.date.available | 2021-09-03T18:51:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10-06 | - |
dc.identifier.issn | 1520-6106 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87198 | - |
dc.description.abstract | Infrared (IR) probes based on terminally blocked beta-isocyanoalanine (AlaNC) and p-isocyanophenylalanine (PheNC) amino acids were synthesized. These isonitrile (NC)-derivatized compounds were extensively characterized by FTIR and femtosecond IR pump-probe spectroscopies, and a direct comparison was made with popularly used nitrile (CN)- and azide (N-3)-derivatized analogs. It is shown that the isonitrile stretch frequency exhibits extremely high sensitivity to hydrogen-bonding interactions. In addition, the IR intensity of the isonitrile group is much higher than that of the nitrile group and almost as intense as that of the azido group. Furthermore, its vibrational lifetime is much longer than that of the nitrile and azido groups. To elucidate the origin of such a high H-bond sensitivity and IR intensity observed for isonitrile, extensive quantum chemical calculations were performed. It is shown that the Coulombic contributions to the vibrational frequency shifts of the isonitrile and nitrile stretch modes have opposite signs but similar magnitudes, whereas the contributions of exchange repulsion and charge delocalization to their frequency shifts are comparable. Therefore, the isonitrile stretch frequency is much more sensitive to H-bonding interactions because the blue-shifting exchange-repulsion effects additionally enforced by such electrostatic effects. It is also shown that the much higher IR intensity of the isonitrile group compared to that of the nitrile group is due to the configuration reversal of the atomic electronegativity between the NC and CN groups. Owing to these features, we believe that isonitrile is a much better IR reporter of H-bonding structure and dynamics than the widely used nitrile and azide. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | 2D IR SPECTROSCOPY | - |
dc.subject | SOLVATOCHROMIC COMPARISON METHOD | - |
dc.subject | INDUCED FREQUENCY-SHIFTS | - |
dc.subject | UNNATURAL AMINO-ACIDS | - |
dc.subject | GAUSSIAN-BASIS SETS | - |
dc.subject | INTERACTION ENERGY | - |
dc.subject | ORGANIC-SOLVENTS | - |
dc.subject | MOLECULAR CALCULATIONS | - |
dc.subject | VIBRATIONAL DYNAMICS | - |
dc.subject | 2D-IR SPECTROSCOPY | - |
dc.title | Isonitrile as an Ultrasensitive Infrared Reporter of Hydrogen-Bonding Structure and Dynamics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwak, Kyungwon | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.contributor.affiliatedAuthor | Cho, Minhaeng | - |
dc.identifier.doi | 10.1021/acs.jpcb.6b04319 | - |
dc.identifier.scopusid | 2-s2.0-84990223845 | - |
dc.identifier.wosid | 000384959200001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY B, v.120, no.39, pp.10167 - 10180 | - |
dc.relation.isPartOf | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.volume | 120 | - |
dc.citation.number | 39 | - |
dc.citation.startPage | 10167 | - |
dc.citation.endPage | 10180 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | 2D IR SPECTROSCOPY | - |
dc.subject.keywordPlus | SOLVATOCHROMIC COMPARISON METHOD | - |
dc.subject.keywordPlus | INDUCED FREQUENCY-SHIFTS | - |
dc.subject.keywordPlus | UNNATURAL AMINO-ACIDS | - |
dc.subject.keywordPlus | GAUSSIAN-BASIS SETS | - |
dc.subject.keywordPlus | INTERACTION ENERGY | - |
dc.subject.keywordPlus | ORGANIC-SOLVENTS | - |
dc.subject.keywordPlus | MOLECULAR CALCULATIONS | - |
dc.subject.keywordPlus | VIBRATIONAL DYNAMICS | - |
dc.subject.keywordPlus | 2D-IR SPECTROSCOPY | - |
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