ScholarWorks@Korea University

Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Two-Photon Tracer for Human Epidermal Growth Factor Receptor-2: Detection of Breast Cancer in a Live Tissue

Full metadata record
DC Field Value Language
dc.contributor.authorChoi, Ji-Woo-
dc.contributor.authorHong, Seung Taek-
dc.contributor.authorKang, Dong Eun-
dc.contributor.authorPaik, Kyu Cheol-
dc.contributor.authorHan, Man So-
dc.contributor.authorLim, Chang Su-
dc.contributor.authorCho, Bong Rae-
dc.date.accessioned2021-09-03T18:53:01Z-
dc.date.available2021-09-03T18:53:01Z-
dc.date.created2021-06-16-
dc.date.issued2016-10-04-
dc.identifier.issn0003-2700-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/87205-
dc.description.abstractWe have developed a two-photon fluorescent tracer (Pyr-affibody) that shows high selectivity for human epidermal growth factor receptor-2 (HER-2). Pyr-affibody showed absorption and emission maxima at 439 and 574 nm, respectively, with a two photon absorption cross-section value of 40 X 10(-50) cm(4)s/photon (GM) at 750 nm in aqueous buffer solution. The effective two photon action cross-section value measured in HeLa cells was 600 GM at 730 nm, a value sufficient to obtain bright two-photon microscopy (TPM) images. Using Pyr-affibody, it was possible to detect HER-2 overexpressing cells and breast cancers at a depth of 90-130 mu m in live mouse tissue by TPM.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectIN-SITU HYBRIDIZATION-
dc.subjectAFFIBODY MOLECULES-
dc.subjectHER-2/NEU-
dc.subjectPROTEIN-
dc.subjectAMPLIFICATION-
dc.subjectMICROSCOPY-
dc.subjectHER2-
dc.subjectOVEREXPRESSION-
dc.subjectCARCINOMAS-
dc.subjectEXPRESSION-
dc.titleTwo-Photon Tracer for Human Epidermal Growth Factor Receptor-2: Detection of Breast Cancer in a Live Tissue-
dc.typeArticle-
dc.contributor.affiliatedAuthorCho, Bong Rae-
dc.identifier.doi10.1021/acs.analchem.6b00912-
dc.identifier.scopusid2-s2.0-84989872106-
dc.identifier.wosid000384842200015-
dc.identifier.bibliographicCitationANALYTICAL CHEMISTRY, v.88, no.19, pp.9412 - 9418-
dc.relation.isPartOfANALYTICAL CHEMISTRY-
dc.citation.titleANALYTICAL CHEMISTRY-
dc.citation.volume88-
dc.citation.number19-
dc.citation.startPage9412-
dc.citation.endPage9418-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.subject.keywordPlusIN-SITU HYBRIDIZATION-
dc.subject.keywordPlusAFFIBODY MOLECULES-
dc.subject.keywordPlusHER-2/NEU-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusAMPLIFICATION-
dc.subject.keywordPlusMICROSCOPY-
dc.subject.keywordPlusHER2-
dc.subject.keywordPlusOVEREXPRESSION-
dc.subject.keywordPlusCARCINOMAS-
dc.subject.keywordPlusEXPRESSION-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Science > Department of Chemistry > 1. Journal Articles
Show simple item record

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

STATISTICS
Total View :8,362,676
Today View :15,823

RSS_1.0 RSS_2.0 ATOM_1.0

CONTACT US

(02841) 서울특별시 성북구 안암로 14502-3290-1114

COPYRIGHT © 2021 Korea University. All Rights Reserved.

Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.

BROWSE

English