Plasticity-augmented psychotherapy for refractory depressive and anxiety disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kwang-Yeon | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-03T18:53:45Z | - |
dc.date.available | 2021-09-03T18:53:45Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10-03 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87209 | - |
dc.description.abstract | Psychotherapy and pharmacotherapy have been the mainstays of treatment for depression and anxiety disorders during the last century. However, treatment response has not improved in the last fewdecades, with only half of all patients responding satisfactorily to typical antidepressants. To fulfill the needs of the remaining patients, new treatments with better efficacy are in demand. The addition of psychotherapy to antidepressant treatment has been shown to be superior to pharmacotherapy alone. However, the time costs of psychotherapy limit its use for clinicians and patients. Advancements in neuroscience have contributed to an improved understanding of the pathogenesis of depressive and anxiety disorders. In particular, recent advances in the field of fear conditioning have provided valuable insight into the treatment of refractory depressive and anxiety disorders. In this review, we studied the reconsolidation-updating paradigm and the concept of epigenetic modification, which has been shown to permanently attenuate remote fear memory. This has implications for drug-augmented, e.g. antidepressant and valproic acid, psychotherapy. Future research on more sophisticated psychotherapy techniques will increase the desirability of this treatment modality for both clinicians and patients. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject | COGNITIVE-BEHAVIORAL THERAPY | - |
dc.subject | HISTONE DEACETYLASE INHIBITORS | - |
dc.subject | OBSESSIVE-COMPULSIVE DISORDER | - |
dc.subject | MEDIAL PREFRONTAL CORTEX | - |
dc.subject | PLACEBO-CONTROLLED TRIAL | - |
dc.subject | CONTEXTUAL FEAR MEMORY | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | SMALLER HIPPOCAMPAL VOLUME | - |
dc.title | Plasticity-augmented psychotherapy for refractory depressive and anxiety disorders | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1016/j.pnpbp.2016.04.003 | - |
dc.identifier.scopusid | 2-s2.0-84964397494 | - |
dc.identifier.wosid | 000378854200017 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.70, pp.134 - 147 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 70 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 147 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject.keywordPlus | COGNITIVE-BEHAVIORAL THERAPY | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE INHIBITORS | - |
dc.subject.keywordPlus | OBSESSIVE-COMPULSIVE DISORDER | - |
dc.subject.keywordPlus | MEDIAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | PLACEBO-CONTROLLED TRIAL | - |
dc.subject.keywordPlus | CONTEXTUAL FEAR MEMORY | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | SMALLER HIPPOCAMPAL VOLUME | - |
dc.subject.keywordAuthor | Reconsolidation | - |
dc.subject.keywordAuthor | Valproate | - |
dc.subject.keywordAuthor | Refractory | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Anxiety disorder | - |
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