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The multilayer nanoparticles for deep penetration of docetaxel into tumor parenchyma to overcome tumor microenvironment

Authors
Ul Khaliq, NisarPark, Dal YongLee, Jae YoungJoo, YeonheeOh, Keun SangKim, Jung SeokKim, Jin-SeokKim, In-SanKwon, Ick ChanYuk, Soon Hong
Issue Date
1-10월-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Deep penetration; Multistage nanostructure; The multilayer nanoparticles; Chemotherapy; Docetaxel
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v.146, pp.833 - 840
Indexed
SCIE
SCOPUS
Journal Title
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume
146
Start Page
833
End Page
840
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87224
DOI
10.1016/j.colsurfb.2016.07.034
ISSN
0927-7765
Abstract
Deep penetration of the anticancer drug, docetaxel (DTX), into tumor parenchyma was demonstrated to achieve improved chemotherapy. For this purpose, a multistage nanostructure was designed and characterized using the multilayer nanoparticles (NPs). The multilayer NPs had a core/shell structure. The core was composed of the DTX-loaded Pluronic NPs (diameter: 12 nm) that were transferred into the inner side of vesicles to form the vesicle NPs. Forster resonance energy transfer (FRET) in the NPs was observed to verify the incorporation of the DTX-loaded Pluronic NPs into the inner side of the vesicles during the formation of the vesicle NPs. Subsequently, the vesicle NPs were stabilized through Pluronic-lipid bilayer interaction to form the multilayer NPs. To examine the morphology and size distribution of the multi layer NPs, transmittance electron microscopy and dynamic light scattering were used. In vitro release behavior and toxicity were observed to verify the functionality of the multilayer NPs as nanocarriers for cancer therapy. Multistage functionality was evaluated by cellular uptake and tissue distribution behaviors of the multilayer NPs. The biodistribution of the multilayer NPs and their antitumor efficacy were also observed to understand the role of multistage functionality for improved chemotherapy. (C) 2016 Elsevier B.V. All rights reserved.
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