Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol
DC Field | Value | Language |
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dc.contributor.author | Lee, Jiyun | - |
dc.contributor.author | Kwon, Gayeung | - |
dc.contributor.author | Park, Jieun | - |
dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Lim, Young-Hee | - |
dc.date.accessioned | 2021-09-03T18:58:44Z | - |
dc.date.available | 2021-09-03T18:58:44Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1535-3702 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87235 | - |
dc.description.abstract | Resveratrol (RES) has been studied for its effects on the lifespan extension of Caenorhabditis elegans, but controversy still remains on its mechanism related with SIR-2. In this study, longevity assay was performed to confirm SIR-2-dependent lifespan extension of C. elgeans with RES and oxyresveratrol (OXY), an isomer of hydroxylated RES using loss-of-function mutants of C. elegans including sir-2.1 mutant. The results showed that OXY and RES significantly (P<0.05) extended the lifespan of C. elegans compared with the control. OXY and RES also significantly (P<0.05) increased the mRNA expression levels of sir-2.1 and aak-2 in a dose-dependent manner and increased the protein expression levels of SIR-2.1. OXY and RES treatment extended the lifespan in daf-16 loss-of-function mutants, which suggested that lifespan extension was not occurring via the activation of DAF-16. However, OXY and RES failed to extend the lifespan in loss-of-function mutants of sir-2.1 and aak-2. Therefore, OXY and RES extend the lifespan of C. elegans by overexpression of SIR-2.1, which is related to lifespan extension through calorie restriction and the AMP-activated protein kinase (AMPK) pathway, although this process is independent of the FOXO/DAF-16 pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | DIETARY RESTRICTION | - |
dc.subject | MEDIATES LONGEVITY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.title | Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hee | - |
dc.identifier.doi | 10.1177/1535370216650054 | - |
dc.identifier.scopusid | 2-s2.0-84988036819 | - |
dc.identifier.wosid | 000383439000005 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL BIOLOGY AND MEDICINE, v.241, no.16, pp.1757 - 1763 | - |
dc.relation.isPartOf | EXPERIMENTAL BIOLOGY AND MEDICINE | - |
dc.citation.title | EXPERIMENTAL BIOLOGY AND MEDICINE | - |
dc.citation.volume | 241 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 1757 | - |
dc.citation.endPage | 1763 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | MEDIATES LONGEVITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | Oxyresveratrol | - |
dc.subject.keywordAuthor | SIR-2 | - |
dc.subject.keywordAuthor | 1 | - |
dc.subject.keywordAuthor | lifespan | - |
dc.subject.keywordAuthor | Caenorhabditis elegans | - |
dc.subject.keywordAuthor | resveratrol | - |
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