Macrophage-Targeted Indocyanine Green-Neomannosyl Human Serum Albumin for Intraoperative Sentinel Lymph Node Mapping in Porcine Esophagus
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun Koo | - |
dc.contributor.author | Quan, Yu Hua | - |
dc.contributor.author | Oh, Yujin | - |
dc.contributor.author | Park, Ji Yong | - |
dc.contributor.author | Park, Ji-Ho | - |
dc.contributor.author | Choi, Yeonho | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Jeong, Jae Min | - |
dc.contributor.author | Choi, Young Ho | - |
dc.contributor.author | Kim, Beop-Min | - |
dc.date.accessioned | 2021-09-03T19:11:03Z | - |
dc.date.available | 2021-09-03T19:11:03Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0003-4975 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87295 | - |
dc.description.abstract | Background. The sentinel lymph node (SLN) concept has been proposed to avoid unnecessary invasive LN dissection in surgery for esophageal cancer. This study evaluated a new macrophage-targeting fluorescent agent, indocyanine green-neomannosyl human serum albumin (ICG: MSA), for SLN mapping using a custom-made intraoperative color and fluorescence-merged imaging system (ICFIS) in porcine esophagus. Methods. The LN targeting ability of ICG: MSA, indocyanine green-human serum albumin (ICG: HSA), and ICG was examined in vitro using the U937 differentiated monocyte cell line and in vivo in a mouse footpad model using fluorescence imaging. SLN identification in rabbit esophagus was then performed using ICG: MSA, ICG: HSA, and ICG. Finally, intraoperative SLN detection was conducted in porcine esophagus after esophagoscopic injection of ICG: MSA. Results. The fluorescence signal of U937 cells treated by ICG: MSA was significantly higher than that of ICG or ICG: HSA(ICG: 1.0 +/- 0.37; ICG: HSA: 3.4 +/- 0.28, ICG: MSA: 6.8 +/- 1.61; ICG to ICG: HSA, p = 0.03; ICG: HSA to ICG: MSA, p = 0.04; ICG to ICG: MSA, p = 0.0009). ICG: MSA was retained in popliteal LNs as long as 3 h, while ICG rapidly diffused through the entire mouse lymphatic system within 5 min. Esophageal SLN was detected within 15 min after injection of either ICG or ICG: MSA, but ICG: MSA provided more distinguishable images of LNss than ICG in rabbit esophagus. The SLN was also successfully detected in all porcine esophagus; the mean number of SLNs identified per esophagus was 1.6 +/- 0.55. Conclusions. ICG: MSA has more specific macrophage-targeting properties, which could overcome the limitation of the low SLN retention of ICG, and could provide more precise real-time SLN detection during esophageal cancer surgery.(C) 2016 by The Society of Thoracic Surgeons. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SQUAMOUS-CELL | - |
dc.subject | BREAST-CANCER | - |
dc.subject | LYMPHADENECTOMY | - |
dc.title | Macrophage-Targeted Indocyanine Green-Neomannosyl Human Serum Albumin for Intraoperative Sentinel Lymph Node Mapping in Porcine Esophagus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Koo | - |
dc.contributor.affiliatedAuthor | Choi, Young Ho | - |
dc.identifier.doi | 10.1016/j.athoracsur.2016.04.077 | - |
dc.identifier.scopusid | 2-s2.0-84977622903 | - |
dc.identifier.wosid | 000389543600049 | - |
dc.identifier.bibliographicCitation | ANNALS OF THORACIC SURGERY, v.102, no.4, pp.1149 - 1155 | - |
dc.relation.isPartOf | ANNALS OF THORACIC SURGERY | - |
dc.citation.title | ANNALS OF THORACIC SURGERY | - |
dc.citation.volume | 102 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1149 | - |
dc.citation.endPage | 1155 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SQUAMOUS-CELL | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | LYMPHADENECTOMY | - |
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