Improved In Vivo Stability of Radioiodinated Rituximab Using an Iodination Linker for Radioimmunotherapy
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun Jung | - |
dc.contributor.author | Kim, Byoung Soo | - |
dc.contributor.author | Choi, Dan Bee | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Choi, Tae Hyun | - |
dc.date.accessioned | 2021-09-03T19:19:55Z | - |
dc.date.available | 2021-09-03T19:19:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1084-9785 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87338 | - |
dc.description.abstract | Purpose: Directly radioiodinated [I-131]-rituximab has been developed as a radioimmunotherapeutic agent in patients with CD20-positive B cell non-Hodgkin's lymphoma. However, there are concerns over its in vivo catabolism and deiodination. A novel radioiodination linker, N-(4-isothiocyanatobenzyl)-2-(3-(tributylstannyl)phenyl) acetamide (IBPA), was synthesized for the preparation of stable radioiodinated proteins. Methods: The authors evaluated the potential of IBPA as a stable radioiodinated linker for rituximab. [I-125]-IBPA was purified and conjugated with rituximab, and in vitro stability testing was performed in serum and liver microsomes. In vivo studies were performed after i.v. injection of [I-125]-rituximab or [I-125]-IBPA-rituximab to nude mice. Results: In in vitro studies, [I-125]-IBPA-rituximab was stable in serum and liver microsomes. In static scans, high radioactivity was evident in the thyroid following injection of [I-125]-rituximab, but low radioactivity was seen in the thyroid following injection of [I-125]-IBPA-rituximab. In biodistribution studies, radioactivity uptake in thyroid glands of [I-125]-IBPA-rituximab was decreased by approximately sevenfold compared to [I-125]-rituximab. In pharmacokinetics, the half-life of [I-125]-rituximab was shorter than that of [I-125]-IBPA-rituximab in plasma of nude mice. Conclusions: The authors demonstrate that [I-125]-IBPA-rituximab is more stable to metabolic deiodination in vivo than is [I-125]-rituximab. Radioiodination of rituximab using IBPA is thus preferable to direct labeling in terms of in vivo stability. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | MURINE MONOCLONAL-ANTIBODY | - |
dc.subject | ENHANCED TUMOR RETENTION | - |
dc.subject | NON-HODGKINS-LYMPHOMA | - |
dc.subject | B-CELL LYMPHOMA | - |
dc.subject | ANTI-CD20 ANTIBODY | - |
dc.subject | I-131 TOSITUMOMAB | - |
dc.subject | SOLID TUMORS | - |
dc.subject | THERAPY | - |
dc.subject | 3-IODOPHENYLISOTHIOCYANATE | - |
dc.subject | RADIOHALOGENATION | - |
dc.title | Improved In Vivo Stability of Radioiodinated Rituximab Using an Iodination Linker for Radioimmunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.identifier.doi | 10.1089/cbr.2016.2047 | - |
dc.identifier.scopusid | 2-s2.0-84992397240 | - |
dc.identifier.wosid | 000386591700003 | - |
dc.identifier.bibliographicCitation | CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, v.31, no.8, pp.287 - 294 | - |
dc.relation.isPartOf | CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | - |
dc.citation.title | CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | - |
dc.citation.volume | 31 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 287 | - |
dc.citation.endPage | 294 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | MURINE MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | ENHANCED TUMOR RETENTION | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | B-CELL LYMPHOMA | - |
dc.subject.keywordPlus | ANTI-CD20 ANTIBODY | - |
dc.subject.keywordPlus | I-131 TOSITUMOMAB | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | 3-IODOPHENYLISOTHIOCYANATE | - |
dc.subject.keywordPlus | RADIOHALOGENATION | - |
dc.subject.keywordAuthor | CD20 | - |
dc.subject.keywordAuthor | deiodination | - |
dc.subject.keywordAuthor | lymphoma | - |
dc.subject.keywordAuthor | N-(4-isothiocyanatobenzyl)-2-(3-(tributylstannyl)phenyl) acetamide (IBPA) | - |
dc.subject.keywordAuthor | radioimmunotherapy | - |
dc.subject.keywordAuthor | rituximab | - |
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