Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2
DC Field | Value | Language |
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dc.contributor.author | An, Hyun-Ju | - |
dc.contributor.author | Kwak, Seo-Young | - |
dc.contributor.author | Yoo, Je-Ok | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Bae, In-Hwa | - |
dc.contributor.author | Park, Myung-Jin | - |
dc.contributor.author | Cho, Mee-Yon | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Han, Young-Hoon | - |
dc.date.accessioned | 2021-09-03T19:23:55Z | - |
dc.date.available | 2021-09-03T19:23:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87356 | - |
dc.description.abstract | MicroRNAs (miRNAs) play pivotal roles in tumorigenesis as either tumor suppressors or oncogenes. In the present study, we discovered and demonstrated the tumor suppressive function of a novel miRNA miR-5582-5p. miR-5582-5p induced apoptosis and cell cycle arrest in cancer cells, but not in normal cells. GAB1, SHC1, and CDK2 were identified as direct targets of miR-5582-5p. Knockdown of GAB1/SHC1 or CDK2 phenocopied the apoptotic or cell cycle arrest-inducing function of miR-5582-5p, respectively. The expression of miR-5582-5p was lower in tumor tissues than in adjacent normal tissues of colorectal cancer patients, while the expression of the target proteins exhibited patterns opposite to that of miR-5582-5p. Intratumoral injection of a miR5582-5p mimic or induced expression of miR-5582-5p in tumor cells suppressed tumor growth in HCT116 xenografts. Collectively, our results suggest a novel tumor suppressive function for miR-5582-5p and its potential applicability for tumor control. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | MICRORNA | - |
dc.subject | PROTEIN | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTOR | - |
dc.subject | MIR-34A | - |
dc.subject | EGF | - |
dc.subject | PROLIFERATION | - |
dc.subject | TRANSLATION | - |
dc.subject | REPRESSION | - |
dc.title | Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1016/j.bbadis.2016.07.017 | - |
dc.identifier.scopusid | 2-s2.0-84979948628 | - |
dc.identifier.wosid | 000382413300009 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v.1862, no.10, pp.1926 - 1937 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.citation.volume | 1862 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1926 | - |
dc.citation.endPage | 1937 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MIR-34A | - |
dc.subject.keywordPlus | EGF | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | miR-5582-5p | - |
dc.subject.keywordAuthor | Tumor suppressor | - |
dc.subject.keywordAuthor | GABI | - |
dc.subject.keywordAuthor | SHC1 | - |
dc.subject.keywordAuthor | CDK2 | - |
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