3D printed alendronate-releasing poly(caprolactone) porous scaffolds enhance osteogenic differentiation and bone formation in rat tibial defects
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.accessioned | 2021-09-03T19:34:35Z | - |
dc.date.available | 2021-09-03T19:34:35Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87407 | - |
dc.description.abstract | The aim of this study was to evaluate the in vitro osteogenic effects and in vivo new bone formation of three-dimensional (3D) printed alendronate (Aln)-releasing poly(caprolactone) (PCL) (Aln/PCL) scaffolds in rat tibial defect models. 3D printed Aln/PCL scaffolds were fabricated via layer-by-layer deposition. The fabricated Aln/PCL scaffolds had high porosity and an interconnected pore structure and showed sustained Aln release. In vitro studies showed that MG-63 cells seeded on the Aln/PCL scaffolds displayed increased alkaline phosphatase (ALP) activity and calcium content in a dose-dependent manner when compared with cell cultures in PCL scaffolds. In addition, in vivo animal studies and histologic evaluation showed that Aln/PCL scaffolds implanted in a rat tibial defect model markedly increased new bone formation and mineralized bone tissues in a dose-dependent manner compared to PCL-only scaffolds. Our results show that 3D printed Aln/PCL scaffolds are promising templates for bone tissue engineering applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | 3-DIMENSIONAL FIBER-DEPOSITION | - |
dc.subject | STEM-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | POLYCAPROLACTONE SCAFFOLDS | - |
dc.subject | OSTEOBLAST PROLIFERATION | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | LOCAL-DELIVERY | - |
dc.subject | DESIGN | - |
dc.subject | STEREOLITHOGRAPHY | - |
dc.subject | BISPHOSPHONATES | - |
dc.title | 3D printed alendronate-releasing poly(caprolactone) porous scaffolds enhance osteogenic differentiation and bone formation in rat tibial defects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1088/1748-6041/11/5/055005 | - |
dc.identifier.scopusid | 2-s2.0-84991678366 | - |
dc.identifier.wosid | 000403492500001 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, v.11, no.5 | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.citation.title | BIOMEDICAL MATERIALS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | 3-DIMENSIONAL FIBER-DEPOSITION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | POLYCAPROLACTONE SCAFFOLDS | - |
dc.subject.keywordPlus | OSTEOBLAST PROLIFERATION | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | LOCAL-DELIVERY | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | STEREOLITHOGRAPHY | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordAuthor | three-dimensional (3D) printed scaffold | - |
dc.subject.keywordAuthor | alendronate | - |
dc.subject.keywordAuthor | MG-63 cells | - |
dc.subject.keywordAuthor | tibial defect model | - |
dc.subject.keywordAuthor | bone formation | - |
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