Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial
- Authors
- An, Jee Hyun; Kim, Dong-Lim; Lee, Tae-Bum; Kim, Kyeong Jin; Kim, Sun Hwa; Kim, Nam Hoon; Kim, Hee Young; Choi, Dong Seop; Kim, Sin Gon
- Issue Date
- 10월-2016
- Publisher
- WILEY
- Keywords
- Rubus occidentalis; black raspberry; metabolic syndrome; prediabetes; atherosclerosis
- Citation
- PHYTOTHERAPY RESEARCH, v.30, no.10, pp.1634 - 1640
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 30
- Number
- 10
- Start Page
- 1634
- End Page
- 1640
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87471
- DOI
- 10.1002/ptr.5664
- ISSN
- 0951-418X
- Abstract
- Rubus occidentalis (RO) has beneficial effects on glucose and lipid profiles in vitro. The aim of the study was to investigate RO extract effect on metabolic parameters in prediabetic patients, adopting a 12-week, randomized, double-blind, placebo-controlled trial. Forty-four patients (age 59.0 +/- 8.2years, 70.5% females, HbA1c 5.8 +/- 0.4%) were divided into placebo (n=13), low-dose RO extract (LRE; n=14), or high-dose RO extract (HRE; n=17) groups. Either 900 or 1800mg per day of RO extract was administered orally. Area under the curve for glucose obtained 2h after a 75-g oral glucose tolerance test was significantly decreased in the HRE group, compared with the placebo group (-28.1 +/- 42.4 vs. +13.4 +/- 52.6mg/dL, p<0.05). Homoeostasis model assessment-B was increased (+17.11 +/- 10.69, +5.24 +/- 4.10, and +0.86 +/- 6.01 in HRE, LRE, and placebo, respectively, p<0.05). Serum levels of monocyte chemoattractant protein-1 and oxidized low-density lipoprotein were significantly decreased by treatment in a dose-dependent manner (monocyte chemoattractant protein-1: -35.0 +/- 21.2, +8.4 +/- 18.1, and +24.2 +/- 14.5; oxidized low-density lipoprotein: -19.7 +/- 8.5, -13.1 +/- 7.2, and -2.2 +/- 11.0 in the HRE, LRE, and placebo, respectively, p<0.05). The results support the beneficial effects of RO extract on the control of glycemia and vascular inflammation in prediabetic patients. (ClinicalTrials.gov: NCT01964703). Copyright (c) 2016 John Wiley & Sons, Ltd.
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