Transcranial focused ultrasound stimulation of human primary visual cortex
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Wonhye | - |
dc.contributor.author | Kim, Hyun-Chul | - |
dc.contributor.author | Jung, Yujin | - |
dc.contributor.author | Chung, Yong An | - |
dc.contributor.author | Song, In-Uk | - |
dc.contributor.author | Lee, Jong-Hwan | - |
dc.contributor.author | Yoo, Seung-Schik | - |
dc.date.accessioned | 2021-09-03T19:56:41Z | - |
dc.date.available | 2021-09-03T19:56:41Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09-23 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87489 | - |
dc.description.abstract | Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans has been limited to the observation of subjective sensory manifestations and electrophysiological responses, thus warranting the identification of stimulated brain regions. Here, we report FUS sonication of the primary visual cortex (V1) in humans, resulting in elicited activation not only from the sonicated brain area, but also from the network of regions involved in visual and higher-order cognitive processes (as revealed by simultaneous acquisition of blood-oxygenation-level-dependent functional magnetic resonance imaging). Accompanying phosphene perception was also reported. The electroencephalo graphic (EEG) responses showed distinct peaks associated with the stimulation. None of the participants showed any adverse effects from the sonication based on neuroimaging and neurological examinations. Retrospective numerical simulation of the acoustic profile showed the presence of individual variability in terms of the location and intensity of the acoustic focus. With exquisite spatial selectivity and capability for depth penetration, FUS may confer a unique utility in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and therapeutic applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NONINVASIVE BRAIN-STIMULATION | - |
dc.subject | LOW-INTENSITY | - |
dc.subject | MAGNETIC STIMULATION | - |
dc.subject | MOTOR | - |
dc.subject | ACTIVATION | - |
dc.subject | THRESHOLD | - |
dc.subject | ATTENTION | - |
dc.subject | RESPONSES | - |
dc.subject | THALAMUS | - |
dc.subject | SYSTEM | - |
dc.title | Transcranial focused ultrasound stimulation of human primary visual cortex | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Hwan | - |
dc.identifier.doi | 10.1038/srep34026 | - |
dc.identifier.scopusid | 2-s2.0-84988598823 | - |
dc.identifier.wosid | 000384046300001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NONINVASIVE BRAIN-STIMULATION | - |
dc.subject.keywordPlus | LOW-INTENSITY | - |
dc.subject.keywordPlus | MAGNETIC STIMULATION | - |
dc.subject.keywordPlus | MOTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | THRESHOLD | - |
dc.subject.keywordPlus | ATTENTION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | THALAMUS | - |
dc.subject.keywordPlus | SYSTEM | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.