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In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound

Authors
Lee, Byung CheolLee, ArimJung, Jee HyungChoi, Sang HoKim, Tae Sung
Issue Date
9월-2016
Publisher
SPANDIDOS PUBL LTD
Keywords
Vibrio vulnificus; psammaplin A; antimicrobial activity
Citation
MOLECULAR MEDICINE REPORTS, v.14, no.3, pp.2691 - 2696
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR MEDICINE REPORTS
Volume
14
Number
3
Start Page
2691
End Page
2696
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87574
DOI
10.3892/mmr.2016.5522
ISSN
1791-2997
Abstract
Vibrio vulnificus is known to induce severely fulminant and fatal septicemia in susceptible hosts. In the present study, the antimicrobial activity of natural marine product-derived compounds against V. vulnificus, were investigated in vitro and in vivo. Twelve pure compounds were isolated from natural marine products and their inhibitory effects on V. vulnificus-induced cytotoxicity were determined in INT-407 cells. Among the 12 pure compounds tested, treatment with psammaplin A significantly suppressed V. vulnificus-induced cytotoxicity in INT-407 cells. Notably, treatment with psammaplin A (5-50 g) had improved survival rates compared with that in the untreated mice, when the mice were infected with V. vulnificus intraperitoneally. In addition, the bacterial load of V. vulnificus in several tissues (spleen, liver and small intestine) was significantly lower in psammaplin A-treated mice than in untreated mice. Furthermore, psammaplin A treatment significantly suppressed the growth of V. vulnificus. Taken together, these results indicate that psammaplin A may be a potential agent for the prevention and treatment of V. vulnificus infections.
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