Surface plasmon resonance sensing of a biomarker of Alzheimer disease in an intensity measurement mode with a bimetallic chip
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyung Jin | - |
dc.contributor.author | Sohn, Young-Soo | - |
dc.contributor.author | Kim, Chang-duk | - |
dc.contributor.author | Jang, Dae-ho | - |
dc.date.accessioned | 2021-09-03T20:22:23Z | - |
dc.date.available | 2021-09-03T20:22:23Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0374-4884 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87614 | - |
dc.description.abstract | A surface plasmon resonance (SPR) sensor system with a bimetallic chip has been utilized to sense the very low concentration of amyloid-beta (A beta)(1-42) by measurement of the reflectance variation. The bimetallic chip was comprised of Au (10 nm) and Ag (40 nm) on Cr (2 nm)-coated BK-7 glass substrate. Protein A was used to efficiently immobilize the antibody of A beta(1-42) on the surface of the bimetallic chip. The reflectance curve of the bimetallic chip represented a narrower linewidth compared to that of the conventional gold (Au) chip. The SPR sensor using the bimetallic chip in the intensity interrogation mode acquired the response of A beta(1-42) at concentrations of 250, 500, 750 and 1,000 pg/ml. The calibration plot showed a linear relationship between the mean reflectance variation and the A beta(1-42) concentration. The results proved that the SPR sensor system with the bimetallic chip in the intensity interrogation mode can successfully detect various concentrations of A beta(1-42), including critical concentration, to help diagnose Alzheimer's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN PHYSICAL SOC | - |
dc.subject | PROTEIN-A | - |
dc.subject | SENSORS | - |
dc.subject | SENSITIVITY | - |
dc.subject | FUTURE | - |
dc.title | Surface plasmon resonance sensing of a biomarker of Alzheimer disease in an intensity measurement mode with a bimetallic chip | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Dae-ho | - |
dc.identifier.doi | 10.3938/jkps.69.793 | - |
dc.identifier.scopusid | 2-s2.0-84990828195 | - |
dc.identifier.wosid | 000384550200017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.69, no.5, pp.793 - 797 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN PHYSICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE KOREAN PHYSICAL SOCIETY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 793 | - |
dc.citation.endPage | 797 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002144456 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Physics, Multidisciplinary | - |
dc.subject.keywordPlus | PROTEIN-A | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | FUTURE | - |
dc.subject.keywordAuthor | Bimetallic chip | - |
dc.subject.keywordAuthor | Surface plasmon resonance | - |
dc.subject.keywordAuthor | Reflectance measurement | - |
dc.subject.keywordAuthor | Amyloid-beta | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.