FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doan, Khanh V. | - |
dc.contributor.author | Kinyua, Ann W. | - |
dc.contributor.author | Yang, Dong Joo | - |
dc.contributor.author | Ko, Chang Mann | - |
dc.contributor.author | Moh, Sang Hyun | - |
dc.contributor.author | Shong, Ko Eun | - |
dc.contributor.author | Kim, Hail | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Kim, Inki | - |
dc.contributor.author | Paik, Ji-Hye | - |
dc.contributor.author | DePinho, Ronald A. | - |
dc.contributor.author | Yoon, Seul Gi | - |
dc.contributor.author | Kim, Il Yong | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Choi, Yun-Hee | - |
dc.contributor.author | Kim, Ki Woo | - |
dc.date.accessioned | 2021-09-03T20:29:44Z | - |
dc.date.available | 2021-09-03T20:29:44Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87650 | - |
dc.description.abstract | Dopaminergic (DA) neurons are involved in the integration of neuronal and hormonal signals to regulate food consumption and energy balance. Forkhead transcriptional factor O1 (FoxO1) in the hypothalamus plays a crucial role in mediation of leptin and insulin function. However, the homoeostatic role of FoxO1 in DA system has not been investigated. Here we report that FoxO1 is highly expressed in DA neurons and mice lacking FoxO1 specifically in the DA neurons (FoxO1 KODAT) show markedly increased energy expenditure and interscapular brown adipose tissue (iBAT) thermogenesis accompanied by reduced fat mass and improved glucose/insulin homoeostasis. Moreover, FoxO1 KODAT mice exhibit an increased sucrose preference in concomitance with higher dopamine and norepinephrine levels. Finally, we found that FoxO1 directly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, delineating a mechanism for the KO phenotypes. Collectively, these results suggest that FoxO1 in DA neurons is an important transcriptional factor that directs the coordinated control of energy balance, thermogenesis and glucose homoeostasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | BROWN ADIPOSE-TISSUE | - |
dc.subject | ORPHAN NUCLEAR RECEPTOR | - |
dc.subject | VENTRAL TEGMENTAL AREA | - |
dc.subject | MICE LACKING FOXO1 | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | GLUCOSE-HOMEOSTASIS | - |
dc.subject | INSULIN SENSITIVITY | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | HYPOTHALAMIC FOXO1 | - |
dc.subject | LOCOMOTOR-ACTIVITY | - |
dc.title | FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Hoon | - |
dc.identifier.doi | 10.1038/ncomms12733 | - |
dc.identifier.scopusid | 2-s2.0-84989846606 | - |
dc.identifier.wosid | 000385285600005 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.7 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | ORPHAN NUCLEAR RECEPTOR | - |
dc.subject.keywordPlus | VENTRAL TEGMENTAL AREA | - |
dc.subject.keywordPlus | MICE LACKING FOXO1 | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | HYPOTHALAMIC FOXO1 | - |
dc.subject.keywordPlus | LOCOMOTOR-ACTIVITY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.