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Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects
- Authors
- Xu, Jing; Li, Shen; Sun, Xiaocong; Ma, Jun; Liu, Feng; Tong, Ling; Lee, Dongho; Ohizumi, Yasushi; Tuerhong, Muhetaer; Guo, Yuanqiang
- Issue Date
- 9월-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Callicarpa kwangtungensis; Abietane diterpenoids; NO inhibitory effects; Diterpenoids; TDDFT ECD calculations
- Citation
- FITOTERAPIA, v.113, pp.151 - 157
- Indexed
- SCIE
SCOPUS
- Journal Title
- FITOTERAPIA
- Volume
- 113
- Start Page
- 151
- End Page
- 157
- ISSN
- 0367-326X
- Abstract
- A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1-3), callipenes A-C, and eleven known analogues (4-14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells. (C) 2016 Published by Elsevier B.V.
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