Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S. -C. | - |
dc.date.accessioned | 2021-09-03T20:48:44Z | - |
dc.date.available | 2021-09-03T20:48:44Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87724 | - |
dc.description.abstract | Objective This study aimed to evaluate the relationship between the 25-hydroxyvitamin D [25(OH) D] level and rheumatoid arthritis (RA) and the correlation between serum vitamin D level and RA activity. Methods We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and prevalence of vitamin D deficiency in patients with RA compared to healthy controls and the correlation coefficients between the vitamin D level and disease activity score 28 (DAS28) in RA patients. Results Fifteen studies that included a total of 1,143 RA patients and 963 controls were available for this meta-analysis. The meta-analysis showed that the serum vitamin D level in the RA group was significantly lower than that in the control group (SMD=-0.608, 95% CI=-1.105-[-0.017], p=0.017). In addition, the prevalence of vitamin D deficiency was significantly higher in the RA group than in the control group (55.2% vs. 33.2%; OR =2.460, 95% CI = 1.135-5.332, p=0.023). Thirteen studies evaluated the correlation between the vitamin D level and its activity in 924 RA patients. Meta-analysis showed a significant inverse correlation between the vitamin D level and DAS28 (Correlation coefficient =-0.278, 95% CI = -0.393-[-0.153], p=1.8 x 10(-5)). Conclusion Our meta-analysis demonstrates that serum vitamin D level is significantly low in patients with RA, vitamin D deficiency is prevalent in RA patients compared to controls, and the vitamin D level correlates inversely with RA activity. Our meta-analysis suggests that the vitamin D level is associated with susceptibility to RA and RA activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CLINICAL & EXPER RHEUMATOLOGY | - |
dc.subject | SERUM 25-HYDROXYVITAMIN D | - |
dc.subject | D DEFICIENCY | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | ASSOCIATION | - |
dc.subject | RISK | - |
dc.title | Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.scopusid | 2-s2.0-84988431508 | - |
dc.identifier.wosid | 000385007500006 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.34, no.5, pp.827 - 833 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 827 | - |
dc.citation.endPage | 833 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SERUM 25-HYDROXYVITAMIN D | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | vitamin D | - |
dc.subject.keywordAuthor | deficiency | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | activity | - |
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