Dual function of MG53 in membrane repair and insulin signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tan, Tao | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.contributor.author | Ma, Jianjie | - |
dc.date.accessioned | 2021-09-03T20:58:33Z | - |
dc.date.available | 2021-09-03T20:58:33Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87776 | - |
dc.description.abstract | MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | LIPID RAFTS REVEALS | - |
dc.subject | MUSCULAR-DYSTROPHY | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | MICE LACKING | - |
dc.subject | MUSCLE | - |
dc.subject | SKELETAL | - |
dc.subject | INJURY | - |
dc.subject | PROTEIN | - |
dc.subject | DYSFERLIN | - |
dc.subject | RESISTANCE | - |
dc.title | Dual function of MG53 in membrane repair and insulin signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.8.079 | - |
dc.identifier.scopusid | 2-s2.0-84992348957 | - |
dc.identifier.wosid | 000384758200004 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.49, no.8, pp.414 - 423 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 414 | - |
dc.citation.endPage | 423 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002137077 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | LIPID RAFTS REVEALS | - |
dc.subject.keywordPlus | MUSCULAR-DYSTROPHY | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | SKELETAL | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DYSFERLIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordAuthor | MG53 | - |
dc.subject.keywordAuthor | TRIM72 | - |
dc.subject.keywordAuthor | E3 ligase | - |
dc.subject.keywordAuthor | Muscular Dystrophy | - |
dc.subject.keywordAuthor | Membrane Repair | - |
dc.subject.keywordAuthor | Insulin Resistance | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.