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Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification

Authors
Do, Hyun JuLee, Youn SueHa, Min JinCho, YoonsuYi, HanaHwang, Yu-JinHwang, Geum-SookShin, Min-Jeong
Issue Date
20-8월-2016
Publisher
JAPAN ENDOCRINE SOC
Keywords
Voglibose; Obesity; Lipid metabolism; Bile acid; Microbiome
Citation
ENDOCRINE JOURNAL, v.63, no.8, pp.691 - 702
Indexed
SCIE
SCOPUS
Journal Title
ENDOCRINE JOURNAL
Volume
63
Number
8
Start Page
691
End Page
702
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87797
ISSN
0918-8959
Abstract
This study was designed with the goal of examining the effects of voglibose administration on body weight and lipid metabolism and underlying mechanism high fat diet-induced obese mice. Male C57BL/6 mice were randomly assigned to one of four groups: a control diet (CTL), high-fat diet (HF), high-fat diet supplemented with voglibose (VO), and high fat diet pair-fed group (PF). After 12 weeks, the following characteristics were investigated: serum lipid and glucose levels, serum polar metabolite profiles, and expression levels of genes involved in lipid and bile acid metabolism. In addition, pyrosequencing was used to analyze the composition of gut microbiota found in feces. Total body weight gain was significantly lower in the VO group than in the CTL, HF, and PF groups. The VO group exhibited improved metabolic profiles including those of blood glucose, triglyceride, and total cholesterol levels. The 12-week voglibose administration decreased the ratio of Firmicutes to Bacteroidetes found in feces. Circulating levels of taurocholic and cholic acid were significantly higher in the VO group than in the HF and CTL groups. Deoxycholic acid levels tended to be higher in the VO group than in the HF group. Voglibose administration downregulated expression levels of CYP8B1 and I-INF4 alpha genes and upregulated those of PGC1 alpha, whereas FXR alpha was not affected. Voglibose administration elicits changes in the composition of the intestinal microbiota and circulating metabolites, which ultimately has systemic effects on body weight and lipid metabolism in mice.
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보건과학대학 (바이오시스템의과학부)
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