Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, Beom-Chan | - |
dc.contributor.author | Hwang, Hyun-Jung | - |
dc.contributor.author | An, Hyoung-Tae | - |
dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Park, Jun-Sub | - |
dc.contributor.author | Hong, Jin | - |
dc.contributor.author | Ko, Jesang | - |
dc.contributor.author | Kim, Chungho | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.date.accessioned | 2021-09-03T21:12:43Z | - |
dc.date.available | 2021-09-03T21:12:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08-02 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87838 | - |
dc.description.abstract | We previously demonstrated that cell-surface gC1qR is a key regulator of lamellipodia formation and cancer metastasis. Here, we screened a monoclonal mouse antibody against gC1qR to prevent cell migration by neutralizing cell-surface gC1qR. The anti-gC1qR antibody prevented growth factor-stimulated lamellipodia formation, cell migration and focal adhesion kinase activation by inactivating receptor tyrosine kinases (RTKs) in various cancer cells such as A549, MDA-MB-231, MCF7 and HeLa cells. The antibody neutralization of cell-surface gC1qR also inhibited angiogenesis because the anti-gC1qR antibody prevented growth factor-stimulated RTK activation, lamellipodia formation, cell migration and tube formation in HUVEC. In addition, we found that A549 tumorigenesis was reduced in a xenograft mouse model by following the administration of the anti-gC1qR antibody. With these data, we can conclude that the antibody neutralization of cell-surface gC1qR could be a good therapeutic strategy for cancer treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.subject | BINDING PROTEIN-1 HABP1/P32/GC1QR | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | FUNCTIONAL EXPRESSION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | GLOBULAR HEADS | - |
dc.subject | TUMOR-CELLS | - |
dc.subject | MIGRATION | - |
dc.subject | RECEPTOR | - |
dc.subject | CANCER | - |
dc.subject | INVASION | - |
dc.title | Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.contributor.affiliatedAuthor | Kim, Chungho | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.18632/oncotarget.10267 | - |
dc.identifier.scopusid | 2-s2.0-84981303304 | - |
dc.identifier.wosid | 000385422000091 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.7, no.31, pp.49972 - 49985 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 7 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 49972 | - |
dc.citation.endPage | 49985 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BINDING PROTEIN-1 HABP1/P32/GC1QR | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | FUNCTIONAL EXPRESSION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | GLOBULAR HEADS | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordAuthor | gC1qR | - |
dc.subject.keywordAuthor | lamellipodia | - |
dc.subject.keywordAuthor | cell migration | - |
dc.subject.keywordAuthor | antibody | - |
dc.subject.keywordAuthor | cancer | - |
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