Sugammadex for reversal of rocuronium-induced neuromuscular blockade in pediatric patients: A systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Won, Young Ju | - |
dc.contributor.author | Lim, Byung Gun | - |
dc.contributor.author | Lee, Dong Kyu | - |
dc.contributor.author | Kim, Heezoo | - |
dc.contributor.author | Kong, Myoung Hoon | - |
dc.contributor.author | Lee, Il Ok | - |
dc.date.accessioned | 2021-09-03T21:27:19Z | - |
dc.date.available | 2021-09-03T21:27:19Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87927 | - |
dc.description.abstract | Background:Previous studies have shown that sugammadex, a modified -cyclodextrin, is a well-tolerated agent for the reversal of neuromuscular blockade (NMB) induced by a steroidal neuromuscular blocking drug in adult patients. However, its use has not been reviewed in pediatric patients. The aim of this meta-analysis was to evaluate the efficacy and safety of sugammadex in the reversal of rocuronium-induced NMB during surgery under general anesthesia in pediatric patients.Methods:A literature search was performed using the Pubmed, EMBASE: Drugs and pharmacology, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. Analysis was conducted using RevMan 5.3. Data collected from different trials were pooled; the weighted mean difference or the pooled risk ratio and the corresponding 95% confidence interval (CI) were used for analysis, and heterogeneity (I-2) assessment was performed.Results:Six randomized controlled trials comparing 253 pediatric patients (age range, 2-18 years) were included in the final analysis. The mean time taken to reach a train-of-four ratio of 0.9 was significantly shorter in the sugammadex groups (2 and 4mg/kg) than in the control group (neostigmine or placebo), although the heterogeneity was high. The weighted mean differences of the 2 and 4mg/kg sugammadex groups were -7.15 (95% CI: -10.77 to -3.54; I-2=96%; P=0.0001) and -17.32 (95% CI: -29.31 to -5.32; I-2=98%; P=0.005), respectively. The extubation time in the sugammadex group was shorter than that in the control group; the weighted mean difference of the sugammadex group was -6.00 (95% CI: -11.46 to -0.53; I-2=99%; P=0.03). There was no significant difference between the groups in terms of the incidence of postanesthetic adverse events; the pooled risk ratio was 0.67 (95% CI: 0.27-1.71; I-2=59%; P=0.41).Conclusion:We suggest that sugammadex is fast and effective in reversing rocuronium-induced NMB in pediatric patients. Although there was no evidence of a higher incidence of adverse events with sugammadex compared to that with neostigmine or placebo, much more data regarding the safety of sugammadex in pediatric patients may be still required. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ENHANCED RECOVERY | - |
dc.subject | PERIOPERATIVE CARE | - |
dc.subject | BLOCKING-AGENTS | - |
dc.subject | SURGERY | - |
dc.subject | NEOSTIGMINE | - |
dc.subject | GUIDELINES | - |
dc.title | Sugammadex for reversal of rocuronium-induced neuromuscular blockade in pediatric patients: A systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Byung Gun | - |
dc.contributor.affiliatedAuthor | Lee, Dong Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Heezoo | - |
dc.contributor.affiliatedAuthor | Kong, Myoung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Il Ok | - |
dc.identifier.doi | 10.1097/MD.0000000000004678 | - |
dc.identifier.scopusid | 2-s2.0-85011954016 | - |
dc.identifier.wosid | 000384032900049 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.95, no.34 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 95 | - |
dc.citation.number | 34 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ENHANCED RECOVERY | - |
dc.subject.keywordPlus | PERIOPERATIVE CARE | - |
dc.subject.keywordPlus | BLOCKING-AGENTS | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | NEOSTIGMINE | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordAuthor | adolescent | - |
dc.subject.keywordAuthor | child | - |
dc.subject.keywordAuthor | neostigmine | - |
dc.subject.keywordAuthor | neuromuscular blockade | - |
dc.subject.keywordAuthor | preschool | - |
dc.subject.keywordAuthor | reversal | - |
dc.subject.keywordAuthor | sugammadex | - |
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