CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7-and IL-15-dependent niches
DC Field | Value | Language |
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dc.contributor.author | Jung, Yong Woo | - |
dc.contributor.author | Kim, Hyun Gyung | - |
dc.contributor.author | Perry, Curtis J. | - |
dc.contributor.author | Kaech, Susan M. | - |
dc.date.accessioned | 2021-09-03T21:52:39Z | - |
dc.date.available | 2021-09-03T21:52:39Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-07-19 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88048 | - |
dc.description.abstract | C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes. The role of this chemokine receptor in regulating the homeostasis of effector and memory T cells during acute viral infection is poorly defined, however. In this study, we show that CCR7 expression alters memory CD8 T-cell homeostasis following lymphocytic choriomeningitis virus infection. Greater numbers of CCR7-deficient memory T cells were formed and maintained compared with CCR7-sufficient memory T cells, especially in the lung and bone marrow. The CCR7-deficient memory T cells also displayed enhanced rates of homeostatic turnover, which may stem from increased exposure to IL-15 as a consequence of reduced exposure to IL-7, because removal of IL-15, but not of IL-7, normalized the numbers of CCR7-sufficient and CCR7-deficient memory CD8 T cells. This result suggests that IL-15 is the predominant cytokine supporting augmentation of the CCR7(-/-) memory CD8 T-cell pool. Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | IN-VIVO | - |
dc.subject | BONE-MARROW | - |
dc.subject | LYMPHOID ORGANS | - |
dc.subject | CUTTING EDGE | - |
dc.subject | EFFECTOR | - |
dc.subject | INFECTION | - |
dc.subject | PHENOTYPE | - |
dc.subject | VIRUS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | IMMUNITY | - |
dc.title | CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7-and IL-15-dependent niches | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.1073/pnas.1602899113 | - |
dc.identifier.scopusid | 2-s2.0-84978858085 | - |
dc.identifier.wosid | 000380224500078 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.29, pp.8278 - 8283 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 113 | - |
dc.citation.number | 29 | - |
dc.citation.startPage | 8278 | - |
dc.citation.endPage | 8283 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | LYMPHOID ORGANS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordAuthor | CCR7 | - |
dc.subject.keywordAuthor | memory T cell | - |
dc.subject.keywordAuthor | IL-7 | - |
dc.subject.keywordAuthor | IL-15 | - |
dc.subject.keywordAuthor | homeostasis | - |
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