Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Weon Sup | - |
dc.contributor.author | Han, Jiyou | - |
dc.contributor.author | Kumar, Rajesh | - |
dc.contributor.author | Lee, Gyung Gyu | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-03T22:08:11Z | - |
dc.date.available | 2021-09-03T22:08:11Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-07-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88087 | - |
dc.description.abstract | We report here a tumor-targeting masked phototherapeutic agent 1 (PT-1). This system contains SN-38-a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated level of topoisomerase I is found in many carcinomas, making it an attractive target for the development of effective anticancer drugs. In addition, PT-1 contains both a photo-triggered moiety (nitrovanillin) and a cancer targeting unit (biotin). Upon light activation in cancer cells, PT-1 interferes with DNA re-ligation, diminishes the expression of topoisomerase I, and enhances the expression of inter alia mitochondrial apoptotic genes, death receptors, and caspase enzymes, inducing DNA damage and eventually leading to apoptosis. In vitro and in vivo studies showed significant inhibition of cancer growth and the hybrid system PT-1 thus shows promise as a programmed photo-therapeutic ("phototheranostic"). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | DNA TOPOISOMERASES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | VIVO | - |
dc.subject | CAMPTOTHECINS | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | MECHANISM | - |
dc.subject | PRODRUG | - |
dc.subject | DESIGN | - |
dc.subject | SN-38 | - |
dc.title | Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1038/srep29018 | - |
dc.identifier.scopusid | 2-s2.0-84977269769 | - |
dc.identifier.wosid | 000379011100001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DNA TOPOISOMERASES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordPlus | CAMPTOTHECINS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | PRODRUG | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SN-38 | - |
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