Alendronate-Modified Hydroxyapatite Nanoparticles for Bone-Specific Dual Delivery of Drug and Bone Mineral
DC Field | Value | Language |
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dc.contributor.author | Hwang, Seok-Joon | - |
dc.contributor.author | Lee, Ji-Seon | - |
dc.contributor.author | Ryu, Tae-Kyung | - |
dc.contributor.author | Kang, Rae-Hyung | - |
dc.contributor.author | Jeong, Ki-Young | - |
dc.contributor.author | Jun, Dae-Ryong | - |
dc.contributor.author | Koh, Jung-Min | - |
dc.contributor.author | Kim, Sung-Eun | - |
dc.contributor.author | Choi, Sung-Wook | - |
dc.date.accessioned | 2021-09-03T22:16:27Z | - |
dc.date.available | 2021-09-03T22:16:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88144 | - |
dc.description.abstract | Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SURFACE-ROUGHNESS | - |
dc.subject | CELL-ADHESION | - |
dc.subject | IN-VITRO | - |
dc.subject | BISPHOSPHONATES | - |
dc.subject | OSTEOPOROSIS | - |
dc.subject | TITANIUM | - |
dc.subject | PROLIFERATION | - |
dc.subject | OSTEOBLASTS | - |
dc.subject | PROTEIN | - |
dc.subject | VIVO | - |
dc.title | Alendronate-Modified Hydroxyapatite Nanoparticles for Bone-Specific Dual Delivery of Drug and Bone Mineral | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung-Eun | - |
dc.identifier.doi | 10.1007/s13233-016-4094-5 | - |
dc.identifier.scopusid | 2-s2.0-84976487063 | - |
dc.identifier.wosid | 000382336000007 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.24, no.7, pp.623 - 628 | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 24 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 623 | - |
dc.citation.endPage | 628 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002128912 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SURFACE-ROUGHNESS | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | TITANIUM | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | OSTEOBLASTS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordAuthor | alendronate | - |
dc.subject.keywordAuthor | hydroxyapatite | - |
dc.subject.keywordAuthor | layer-by-layer method | - |
dc.subject.keywordAuthor | dual targeted delivery | - |
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