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Morphometric Analysis of Thyroid Follicular Cells with Atypia of Undetermined Significance

Authors
Kang, YoungjinLee, Yoo JinJung, JiyoonLee, YoungseokWon, Nam HeeChae, Yang Seok
Issue Date
7월-2016
Publisher
KOREAN SOC PATHOLOGISTS
Keywords
Atypia of undetermined significance; Morphometric analysis; Thyroid
Citation
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, v.50, no.4, pp.287 - 293
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
Volume
50
Number
4
Start Page
287
End Page
293
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/88146
DOI
10.4132/jptm.2016.04.04
ISSN
2383-7837
Abstract
Background: Atypia of undetermined significance (AUS) is a category that encompasses a heterogeneous group of thyroid aspiration cytology. It has been reclassified into two subgroups based on the cytomorphologic features: AUS with cytologic atypia and AUS with architectural atypia. The nuclear characteristics of AUS with cytologic atypia need to be clarified by comparing to those observed in Hashimoto thyroiditis and benign follicular lesions. Methods: We selected 84 cases of AUS with histologic follow-up, 24 cases of Hashimoto thyroiditis, and 26 cases of benign follicular lesions. We also subcategorized the AUS group according to the follow-up biopsy results into a papillary carcinoma group and a nodular hyperplasia group. The differences in morphometric parameters, including the nuclear areas and perimeters, were compared between these groups. Results: The AUS group had significantly smaller nuclear areas than the Hashimoto thyroiditis group, but the nuclear perimeters were not statistically different. The AUS group also had significantly smaller nuclear areas than the benign follicular lesion group; however, the AUS group had significantly longer nuclear perimeters. The nuclear areas in the papillary carcinoma group were significantly smaller than those in the nodular hyperplasia group; however, the nuclear perimeters were not statistically different. Conclusions: We found the AUS group to be a heterogeneous entity, including histologic follow-up diagnoses of papillary carcinoma and nodular hyperplasia. The AUS group showed significantly greater nuclear irregularities than the other two groups. Utilizing these features, nuclear morphometry could lead to improvements in the accuracy of the subjective diagnoses made with thyroid aspiration cytology.
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