Brief Isolation Changes Nociceptive Behaviors and Compromises Drug Tests in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Rafael Taeho | - |
dc.contributor.author | Lee, Hyunkyoung | - |
dc.contributor.author | Lee, JaeHee | - |
dc.contributor.author | Lee, Sat-Byol | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Back, Seung Keun | - |
dc.contributor.author | Na, Heung Sik | - |
dc.date.accessioned | 2021-09-03T22:28:14Z | - |
dc.date.available | 2021-09-03T22:28:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1530-7085 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88231 | - |
dc.description.abstract | Herding with a litter is known to comfort rodents, whereas isolation and grouping with noncagemates provoke stress. The effects of stress induced by isolation and grouping with noncagemates on pain responses, and their underlying mechanisms remain elusive. We assessed the effect of isolation, a common condition during behavioral tests, and of grouping on defecation and pain behaviors of mice. Fecal pellets were counted 2hours after exposure to the test chamber. It is significantly more in the isolated mice than in the grouped mice. Hindpaw withdrawal threshold and withdrawal latency were adopted as the indicatives of mechanical and thermal pain sensitivities, respectively. Interestingly, isolated mice showed higher pain thresholds than mice grouping with cagemates, and even those with noncagemates, indicating analgesic effects. Such effects were reduced by intrathecal injection of 0.01mg/kg of naloxone (opioid receptor antagonist), atosiban (oxytocin and vasopressin receptor antagonist), and ketanserin (5-HT receptor antagonist). Intraperitoneal delivery of 1mg/kg of naloxone and atosiban, but not ketanserin, also alleviated the isolation-induced analgesic effects. In contrast, these drugs at the same dose had no significant effect on the mice grouping with cagemates. In addition, the effect of morphine on thermal pain was more robust in the mice grouping with cagemates than in the isolated mice. These data demonstrated that brief isolation caused analgesia, mediated by endogenous opioidergic, oxytocinergic, and serotonergic pathways. These results indicate that isolation during pain behavioral tests can affect pain responses and the efficacy of drugs; thus, nociception tests should be conducted in grouping. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | STRESS-INDUCED ANALGESIA | - |
dc.subject | SOCIAL-ISOLATION | - |
dc.subject | PAIN | - |
dc.subject | OXYTOCIN | - |
dc.subject | RECEPTOR | - |
dc.subject | MORPHINE | - |
dc.subject | RATS | - |
dc.subject | HYPERALGESIA | - |
dc.subject | MODULATION | - |
dc.subject | SEROTONIN | - |
dc.title | Brief Isolation Changes Nociceptive Behaviors and Compromises Drug Tests in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.1111/papr.12325 | - |
dc.identifier.scopusid | 2-s2.0-84977498347 | - |
dc.identifier.wosid | 000379895100012 | - |
dc.identifier.bibliographicCitation | PAIN PRACTICE, v.16, no.6, pp.749 - 757 | - |
dc.relation.isPartOf | PAIN PRACTICE | - |
dc.citation.title | PAIN PRACTICE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 749 | - |
dc.citation.endPage | 757 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | STRESS-INDUCED ANALGESIA | - |
dc.subject.keywordPlus | SOCIAL-ISOLATION | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | OXYTOCIN | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MORPHINE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordAuthor | analgesics | - |
dc.subject.keywordAuthor | drug testing | - |
dc.subject.keywordAuthor | pain assessment | - |
dc.subject.keywordAuthor | pain behaviors | - |
dc.subject.keywordAuthor | animal models | - |
dc.subject.keywordAuthor | isolation | - |
dc.subject.keywordAuthor | rodent | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.